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The Association between Serum Follistatin-like Proteins and Cardiovascular Diseases: A Systematic Review and Meta-analysis

  • 0Transplant Research Center, Clinical Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Current Cardiology Reviews +

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July 22, 2024

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July 22, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Follistatin-like protein 1 (FSTL1) levels are significantly higher in individuals with cardiovascular diseases (CVDs). This finding suggests FSTL1 may serve as a potential biomarker for diagnosing and predicting CVD outcomes.

Area Of Science

  • Biochemistry
  • Cardiology
  • Endocrinology

Background

  • Follistatin-like proteins (FSTLs) are adipomyokines secreted by adipocytes and myocytes.
  • Elevated circulating FSTL1 levels have been observed following cardiovascular injuries.
  • This study systematically reviews the association between FSTLs and cardiovascular diseases (CVDs).

Approach

  • A comprehensive literature search was conducted across major scientific databases.
  • Eligible studies were screened, data extracted, and a meta-analysis performed using Standardized Mean Difference (SMD).
  • Sensitivity analyses and publication bias assessments were performed to ensure robustness.

Key Points

  • Five studies involving 941 CVD cases and 446 controls were included.
  • Circulating FSTL1 levels were significantly higher in CVD patients compared to controls (SMD = 0.853, P = 0.016).
  • Heterogeneity was identified, primarily linked to a study on heart failure with preserved ejection fraction.

Conclusions

  • FSTL1 is significantly elevated in patients with cardiovascular diseases.
  • FSTL1 shows potential as a diagnostic and prognostic biomarker for CVD.
  • Further research is warranted to confirm the clinical utility of FSTL1 in CVD management.

Keywords:

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