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Ganglioside GD3: structure, cellular distribution, and possible function.

T N Seyfried, R K Yu

    Molecular and Cellular Biochemistry
    |September 1, 1985
    PubMed
    Summary
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    Ganglioside GD3 is found in many neural cell types. Its distribution suggests ganglioside GD3 may enhance cell membrane permeability, impacting cell functions.

    Area of Science:

    • Neuroscience
    • Cell Biology
    • Biochemistry

    Background:

    • Gangliosides are complex glycosphingolipids crucial for cell function.
    • Understanding ganglioside function requires knowledge of their cellular distribution.
    • Ganglioside GD3 is a specific type with implications in various biological processes.

    Purpose of the Study:

    • To review the structure of ganglioside GD3.
    • To present recent findings on the cellular distribution of ganglioside GD3.
    • To propose a functional role for ganglioside GD3 based on its distribution.

    Main Methods:

    • Literature review of ganglioside GD3 structure.
    • Compilation and analysis of studies reporting GD3 cellular localization.
    • Correlation of GD3 distribution with known cell properties.

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    Main Results:

    • Ganglioside GD3 is enriched in specific neural cell types, including reactive glia, gliomas, undifferentiated neurons, Muller glia, and oligodendroglia.
    • These enriched cell types exhibit properties associated with enhanced membrane permeability to ions and metabolites.
    • A pattern emerges linking GD3 presence with enhanced membrane permeability.

    Conclusions:

    • Ganglioside GD3 is strongly associated with enhanced membrane permeability in neural cells.
    • This association suggests a functional role for GD3 in regulating membrane transport.
    • Potential implications of GD3's role in membrane permeability extend to cellular metabolism, growth, and intercellular interactions.