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Related Concept Videos

Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

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Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
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Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives01:22

Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives

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Laxatives enhance bowel movements and alleviate constipation. They augment the stool's bulk, stimulate intestinal muscle contractions, draw water into the intestines, or soften the stool. There are five key types of laxatives: bulk laxatives, stimulant laxatives, osmotic laxatives, stool softeners, and lubricant laxatives.
Bulk-forming laxatives, such as psyllium, methylcellulose, and polycarbophil, absorb water in the intestine, increasing stool bulk and promoting bowel movement. This...
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Drugs for Treatment of Diarrhea-Predominant IBS01:17

Drugs for Treatment of Diarrhea-Predominant IBS

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Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
156
Drugs Affecting GI Tract Motility: Other Laxatives01:20

Drugs Affecting GI Tract Motility: Other Laxatives

186
Laxatives are primarily used to alleviate constipation, a common gastrointestinal disorder characterized by infrequent bowel movements and difficulty passing stools. They work by various mechanisms to increase the volume or frequency of bowel movements. The primary modes of action of laxatives include increasing stool bulk, softening the stool, stimulating intestinal motility, and osmotically drawing water into the intestines.
Osmotic or saline laxatives, like magnesium hydroxide or milk of...
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Inflammatory Bowel Disease V: Surgical Management01:21

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
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Irritable Bowel Syndrome III: Medical and Nursing Management01:30

Irritable Bowel Syndrome III: Medical and Nursing Management

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Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
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Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation
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Recent advances in treating constipation in children.

Sharon Wolfson1, Miguel Saps2

  • 1Division of Pediatric Gastroenterology, Hepatology and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Expert Review of Gastroenterology & Hepatology
|July 22, 2024
PubMed
Summary
This summary is machine-generated.

New therapies are emerging for pediatric functional constipation (FC), a common condition. While linaclotide is now FDA-approved for children, further research on safety and efficacy is crucial for personalized FC management.

Keywords:
5 HT-4 agonistabsorbagoguefunctional constipationneurostimulationosmotic laxativepediatricssecretory agentsstimulant laxative

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Area of Science:

  • Pediatric Gastroenterology
  • Pharmacology
  • Surgical Interventions

Background:

  • Functional constipation (FC) affects a significant number of children, with approximately 30% not responding to standard treatments.
  • Current management often involves lifestyle changes and osmotic laxatives, but new therapeutic avenues are becoming available.

Purpose of the Study:

  • To review current and emerging pharmacologic, surgical, and neuromodulatory therapies for pediatric functional constipation.
  • To discuss the efficacy and safety data for these diverse treatment modalities in children.

Main Methods:

  • Literature review of existing and novel therapeutic options for pediatric FC.
  • Analysis of efficacy and safety data from clinical studies and expert opinions.

Main Results:

  • The first pharmacologic agent, linaclotide, received FDA approval in 2023 for treating FC in children aged 6-17 years.
  • Various pharmacologic, surgical, and neuromodulatory approaches are being explored for pediatric FC management.

Conclusions:

  • Further investigation into the safety and efficacy of new FC treatments in pediatric populations is essential.
  • A personalized approach to pediatric FC management, considering distinct pathophysiology from adults, is predicted to improve outcomes.