Related Experiment Video

Updated: May 11, 2026

Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma
06:15

Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma

Published on: October 27, 2014

27.4K

A Triple Laser Combination Treatment for Facial Angiofibromata Management in Tuberous Sclerosis and Literature Review

F Neamonitou1, K K Neamonitos2, S Stavrianos1

  • 1Department of Plastic Surgery, General Anticancer Oncological Hospital of Athens 'Saint Savvas', Athens, Greece.

Archives of Plastic Surgery
|July 22, 2024
PubMed

Insights

A new triple laser therapy protocol effectively manages facial angiofibromas in tuberous sclerosis patients, showing high satisfaction and minimal recurrence after two years. This treatment offers a safe and compliant option for dermatological practice.

Area of Science:

  • Dermatology
  • Laser Therapy
  • Tuberous Sclerosis

Background:

  • Facial angiofibromas are a common symptom of tuberous sclerosis (TS).
  • Existing treatments for angiofibromas have limited efficacy due to high recurrence rates and poor patient compliance.
  • There is a need for improved therapeutic strategies for managing facial angiofibromas in TS patients.

Purpose of the Study:

  • To evaluate the efficacy and safety of a novel triple sequential laser therapy protocol for treating facial angiofibromas in patients with tuberous sclerosis.
  • To assess patient outcomes using the Facial Angiofibromata Severity Index (FASI) and Dermatology Life Quality Index (DLQI).

Main Methods:

  • A prospective study involving 10 patients (4 female, 6 male; mean age 26.3 years) with TS and facial angiofibromas.
  • Patients received triple sequential laser therapy between January 2000 and December 2022.
  • Outcomes were assessed via clinical photography (FASI scores) at baseline, 6 months, 1 year, and 2 years, along with DLQI assessments.

Main Results:

  • All 10 patients achieved successful recovery without complications.
  • Four patients experienced localized recurrences at 6 months, successfully treated with a single carbon dioxide laser session.
  • After 2 years, no recurring facial cutaneous manifestations were observed, with all patients showing decreased FASI scores.
  • Patient satisfaction was high (95% on Visual Analogue Scale), and DLQI indicated minimal impact on daily life.

Conclusions:

  • The triple sequential laser therapy protocol is an effective, safe, and compliant treatment for facial angiofibromas associated with tuberous sclerosis.
  • This approach provides satisfactory outcomes and is adaptable for routine dermatological and plastic surgery practices.
  • The study demonstrates long-term efficacy in preventing recurrence and improving quality of life for TS patients with angiofibromas.
Keywords:
Erbiumangiofibromalaserpulsed dye lasertuberous sclerosis

More Related Videos

Focal Laser Ablation of Prostate Cancer: An Office Procedure11:07

Focal Laser Ablation of Prostate Cancer: An Office Procedure

Published on: March 30, 2021

7.8K
Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application03:47

Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application

Published on: September 27, 2024

845

Related Concept Videos

Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
Rheumatic Heart Disease III: Medical Management01:21

Rheumatic Heart Disease III: Medical Management

Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
Aneurysm III: Interprofessional Care01:26

Aneurysm III: Interprofessional Care

Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...