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Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
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Occlusion dysfunction and Alzheimer's disease: Mendelian randomization study.

Qing Wang1, Wenyu Zhen1, Rui Hu2

  • 1Key Laboratory of Oral Diseases Research of Anhui Province, College and Hospital of Stomatology, Anhui Medical University, Hefei, China.

Frontiers in Aging Neuroscience
|July 22, 2024
PubMed
Summary

Loose teeth significantly increase Alzheimer's disease risk, while restoring occlusion may protect neurological health. This study investigated the causal link between occlusion dysfunction and Alzheimer's disease.

Keywords:
Alzheimer’s diseaseMendelian randomizationepidemiologyocclusion dysfunctionperiodontal disease

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Area of Science:

  • Neurology
  • Genetics
  • Dental Science

Background:

  • Alzheimer's disease (AD) is a progressive neurodegenerative disorder.
  • Occlusion dysfunction (OD) is increasingly recognized as a potential contributing factor to AD.
  • Understanding the causal relationship between OD and AD is crucial for developing preventative strategies.

Purpose of the Study:

  • To investigate the causal relationship between occlusion dysfunction and Alzheimer's disease using Mendelian randomization (MR).
  • To assess the impact of periodontal disease (PD), loose teeth, and denture restoration on AD risk.

Main Methods:

  • Utilized genome-wide association study (GWAS) meta-analysis data from large biobanks (FinnGen, IEU Open GWAS, UK Biobank).
  • Employed Mendelian randomization (MR) analysis to establish causal inference.
  • Validated the relationship between oral health indicators and AD.

Main Results:

  • No direct causal relationship was found between periodontal disease (PD) and AD (P = 0.395).
  • Loose teeth were significantly associated with an increased risk of AD progression (P = 0.017, OR = 187.36).
  • Denture restoration demonstrated a protective effect, showing a negative causal relationship with AD (P = 0.015, OR = 0.023).

Conclusions:

  • Occlusion dysfunction can be a potential inducer of Alzheimer's disease.
  • Maintaining proper occlusion function may serve as a protective factor for neurological health.