Related Experiment Video
Updated: Jun 20, 2025
A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
Published on: September 20, 2019
Benefits and Risks of Preprepared Parenteral Nutrition for Early Amino Acid Administration in Premature Infants with
Pin-Chun Chen1,2, Hsin-Chung Huang3, Mei-Jy Jeng2,4,5
1Department of Pharmacy, Taipei City Hospital, Taipei City, Taiwan.
Insights
Advance-prepared parenteral nutrition (PN) safely supports very low birth weight (VLBW) infants, providing earlier amino acid delivery and improved head growth. This method is beneficial where sterile compounding is limited.
Area of Science:
- Neonatalogy
- Pediatric Nutrition
- Clinical Pharmacy
Background:
- Administering early parenteral nutrition (PN) to very low birth weight (VLBW) infants is challenging due to logistical and facility constraints.
- Advance-prepared PN offers a potential solution to overcome these barriers.
Purpose of the Study:
- To evaluate the safety and benefits of using advance-prepared PN in VLBW infants.
- To compare early amino acid intake and growth outcomes between traditional and advance-prepared PN groups.
Main Methods:
- A retrospective study of VLBW infants receiving PN for at least seven days between July 2015 and August 2019.
- Infants were divided into a traditional PN group and an advance-prepared PN group.
Main Results:
- The advance-prepared PN group received significantly higher amino acid intake in the initial two days.
- The advance-prepared PN group showed improved head circumference growth ratio at day 7 and day 21.
- No significant differences in metabolic tolerance were observed between groups.
Conclusions:
- Advance-prepared PN can be safely implemented in VLBW preterm infants.
- This strategy enhances early amino acid delivery and promotes better head growth within 21 days.
- Advance-prepared PN is a viable alternative for facilities with limited sterile compounding access.
Purpose:
Administering early parenteral amino acids to very low birth weight (VLBW) premature infants (birth body weight [BBW]<1,500 g) is challenging due to factors such as holidays, cost, and access to sterile compounding facilities. Using advance-prepared parenteral nutrition (PN) may address this issue and should be evaluated for its safety and potential benefits.
Methods:
We extracted data from medical records collected between July 2015 and August 2019. VLBW infants received PN for at least seven days and were split into two groups: the traditional group (n=30), which initially received a glucose solution and then PN on workdays, and the pre-preparation group (n=16), which received advance-prepared PN immediately upon admission to the neonatal intensive care unit.
Results:
The median BBWs of the traditional and pre-preparation groups were 1,180.0 vs. 1,210.0 g. In the initial two days, the pre-preparation group had a significantly higher amino acid intake (2.23 and 2.24 g/kg/d) than the traditional group (0 and 1.78 g/kg/d). The pre-preparation group exhibited greater head circumference growth ratio relative to birth (7th day: 1.21% vs. -3.57%, p=0.014; 21st day: 7.71% vs. 3.31%, p=0.017). No significant differences in metabolic tolerance were observed.
Conclusion:
Advanced preparation of PN can be safely implemented in VLBW preterm infants, offering advantages such as early, higher amino acid intake and improved head circumference growth within the first 21 days post-birth. This strategy may serve as a viable alternative in settings where immediate provision of sterile compounding facilities is challenging.
More Related Videos
09:36Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers
Published on: July 28, 2022
07:36Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Published on: November 20, 2015
Related Concept Videos
01:27Parentral Nutrition: Centeral and Peripheral Parental Nutrition
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
01:15Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube...
01:25Routes of Drug Administration: Parenteral
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
01:21Factors Affecting Drug Response: Overview
01:29Drug Delivery: Parenteral Route
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
01:24Parenteral Anesthetics: Overview