Spontaneous cortical activity is altered in persons with HIV and related to domain-specific cognitive function
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View abstract on PubMed
Summary
This summary is machine-generated.People with HIV show altered brain activity, particularly in areas linked to higher-order thinking. This spontaneous neural activity may explain cognitive deficits in individuals with HIV.
Area Of Science
- Neuroscience
- Neurovirology
- Cognitive Science
Background
- Individuals with HIV have a higher risk of cognitive impairment despite increased life expectancy.
- Previous research indicates HIV affects sensory and association cortices.
- Elevated spontaneous cortical activity is noted in neuroHIV studies, but less is known about resting-state conditions.
Purpose Of The Study
- To investigate spontaneous cortical activity in persons with HIV using magnetoencephalography (MEG).
- To correlate neural activity with cognitive function performance.
- To understand how HIV impacts brain activity and cognitive function.
Main Methods
- Magnetoencephalography (MEG) was used to measure spontaneous cortical activity.
- 79 persons with HIV and 83 seronegative controls participated.
- Participants underwent neuropsychological assessments.
Main Results
- Persons with HIV exhibited stronger spontaneous gamma activity in specific brain regions (inferior parietal, prefrontal, superior temporal cortices).
- Serostatus influenced the link between spontaneous beta activity and cognitive performance; controls showed better performance with higher beta activity.
- HIV appears to predominantly affect spontaneous activity in association cortices.
Conclusions
- HIV impacts spontaneous neural activity in association cortices, suggesting alterations in higher-order brain function.
- Deficient GABAergic signaling may underlie the observed gamma and beta oscillation abnormalities.
- Findings link aberrant spontaneous activity in persons with HIV to domain-specific cognitive dysfunction.
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