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A Meta-analysis to Quantify the Risk of Disseminated Gonococcal Infection With Porin B Serotype
Geoffrey Welch1, George W Reed1, Peter A Rice1
1Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.
Globally rising gonorrhea rates correlate with increased disseminated gonococcal infection (DGI). Gonorrhea strains expressing the PorB1A protein are significantly more likely to cause DGI compared to PorB1B strains.
Area of Science:
- Microbiology
- Infectious Diseases
- Genetics
Background:
- Gonorrhea rates are increasing worldwide.
- Disseminated gonococcal infection (DGI) is a severe complication of gonorrhea.
- The outer membrane protein PorB is crucial for Neisseria gonorrhoeae pathogenesis.
Purpose of the Study:
- To investigate the association between Neisseria gonorrhoeae outer membrane protein PorB variants and DGI.
- To quantify the risk of dissemination for strains expressing the PorB1A allele.
Main Methods:
- A meta-analysis was conducted.
- Data from multiple studies on gonorrhea isolates and DGI cases were synthesized.
- Statistical analysis was performed to compare the odds of dissemination between different PorB alleles.
Main Results:
- The expression of the PorB1A allele in Neisseria gonorrhoeae is significantly associated with DGI.
- Strains with the PorB1A allele had 20.53 times higher odds of causing disseminated infection compared to strains with the PorB1B allele.
Conclusions:
- The PorB1A allele is a key factor contributing to the increased incidence of DGI.
- Understanding the role of PorB variants can inform strategies for preventing and treating gonorrhea complications.
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