Related Experiment Video
Updated: Jun 20, 2025
Mouse Models for Graft Arteriosclerosis
Published on: May 14, 2013
Graft versus histoplasma disease: A case of vascular graft infection
Racha Ghoussaini1, Omar Abu Saleh2, Hussam Tabaja2
1Department of Internal Medicine, American University of Beirut Medical Center, Faculty of Medicine, Beirut, Lebanon.
Abstract:
Histoplasma vascular graft infection (VGI) is rarely reported, with only a handful of instances documented in the existing literature. Reporting Histoplasma VGI cases is important as they demonstrate previous treatment strategies and their outcomes. In this paper, we report a case of disseminated histoplasmosis with ascending aortic graft infection. Conservative therapy was attempted initially but failed, and our patient eventually required surgical graft explantation. Our case demonstrates the challenges in diagnosing and managing VGI caused by Histoplasma capsulatum.
Insights
Histoplasma vascular graft infection is rare. This case highlights challenges in diagnosis and management, showing conservative therapy failed, necessitating surgical graft explantation for disseminated histoplasmosis.
Area of Science:
- Mycology
- Infectious Diseases
- Cardiovascular Surgery
Background:
- Histoplasma vascular graft infection (VGI) is an uncommon but serious complication.
- Disseminated histoplasmosis can affect various organs, including prosthetic materials.
Observation:
- A case of disseminated histoplasmosis involving an ascending aortic graft is presented.
- The patient initially received conservative therapy for the infection.
Findings:
- Conservative treatment for Histoplasma VGI proved ineffective.
- Surgical explantation of the infected vascular graft was ultimately required.
Implications:
- This case underscores the diagnostic and therapeutic difficulties associated with Histoplasma VGI.
- Effective management strategies for this rare condition require further investigation and reporting.
Related Concept Videos
01:24Tissue Transplantation
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
01:40Cell-mediated Immune Responses
01:23Skin Diseases and Disorders
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
01:22Bone Marrow Sampling and Transplants
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...