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Infection-Related Glomerulonephritis Due to Subacute Bacterial Endocarditis in the Aortic Valve: A Case Report

Sushrut Gupta1, Pranjal Kashiv1, Sunny Malde1

  • 1Nephrology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.

Cureus
|July 22, 2024
PubMed

Insights

Infection-related glomerulonephritis (IRGN) is a rare kidney complication of bacterial infections like subacute bacterial endocarditis (SBE). Prompt diagnosis and multidisciplinary care are crucial for managing SBE-associated IRGN and preventing severe kidney damage.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Cardiology

Background:

  • Infection-related glomerulonephritis (IRGN) is a serious kidney disease often triggered by bacterial infections.
  • Subacute bacterial endocarditis (SBE) is a significant, though less common, cause of IRGN.
  • Early recognition and management are vital to prevent long-term renal complications.

Observation:

  • A 15-year-old male presented with edema, frothy urine, and shortness of breath.
  • Investigations confirmed infective endocarditis and abnormal kidney function.
  • Blood cultures identified Burkholderia cepacia and MR-CoNS.

Findings:

  • Kidney biopsy revealed immune complex-mediated glomerulonephritis.
  • The patient required extensive medical support, including hemodialysis and antibiotics.
  • Successful treatment involved a multidisciplinary approach.

Implications:

  • This case underscores the importance of suspecting IRGN in patients with SBE.
  • Timely intervention can mitigate severe renal damage and systemic effects.
  • Highlights the need for integrated care in complex infectious and renal conditions.
Keywords:
antibioticsburkholderia cepaciaendocarditisglomerulonephritishemodialysiskidney biopsy

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