Related Experiment Video
Updated: May 8, 2026
07:55
Ex Vivo Organotypic Corneal Model of Acute Epithelial Herpes Simplex Virus Type I Infection
Published on: November 3, 2012
12.8K
Herpes Simplex Virus (HSV)-Induced Erythema Multiforme: A Rare Case Report
Sourabh B Shinde1, Vidya Lohe1, Swapnil Mohod1
1Oral Medicine and Radiology, Sharad Pawar Dental College and Hospital, Wardha, IND.
Cureus
|July 22, 2024
Summary
Erythema multiforme (EM), often linked to herpes simplex virus (HSV), presents as recurrent skin lesions. This case highlights successful treatment of severe HSV-associated EM with a combination therapy, preventing recurrence.
Area of Science:
- Dermatology
- Infectious Diseases
Background:
- Erythema multiforme (EM) is an acute, self-limiting, immune-mediated mucocutaneous condition.
- Herpes simplex virus (HSV) is a frequent trigger for EM, particularly in adults, often presenting with recurrent episodes.
Observation:
- A 45-year-old patient presented with severe oral ulcerations, pain, and burning, indicative of recurrent EM.
- The patient reported a history of similar, less severe oral ulcers two months prior, which resolved spontaneously.
Findings:
- The recurrent episode of HSV-associated EM exhibited increased pain and inflammation compared to the previous occurrence.
- Combination therapy including antivirals, steroids, silymarin, and multivitamins was administered over four visits with a steroid taper.
Implications:
- Successful treatment with the combination therapy led to the complete resolution of EM symptoms.
- The patient experienced no recurrence and regained the ability to masticate and swallow without discomfort, demonstrating effective management of HSV-associated EM.
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