Netherton Syndrome in Thai Children: A Report of Two Cases With a Literature Review
Panipak Temboonnark1,2, Tassalapa Daengsuwan1,2
1Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, Queen Sirikit National Institute of Child Health, Bangkok, THA.
Abstract:
Netherton syndrome (NS) is a severe autosomal recessive disorder characterized by the triad of congenital ichthyosiform erythroderma, trichorrhexis invaginata, and atopic diathesis. We report two cases that experienced severe congenital exfoliative dermatitis, recurrent infections, and allergic conditions. Examinations of hair under the light microscope revealed trichorrhexis invaginata. Whole exome sequencing identified homologous pathogenic mutations of SPINK5. Optimal skincare and proper nutritional support could improve patients' quality of life.
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