Astaxanthin and improvement of dementia: A systematic review of current clinical trials

Area of Science:

• Neuroscience
• Gerontology
• Nutritional Science

Background:

• Neurodegenerative diseases, particularly dementia, are increasing globally due to population aging.
• Oxidative stress and free radicals exacerbate dementia progression.
• Astaxanthin, a marine carotenoid, has demonstrated neuroprotective effects in preclinical models.

Purpose of the Study:

• To review clinical trial evidence on Astaxanthin's benefits for cognitive function in older adults.
• To assess the safety and efficacy of Astaxanthin supplementation for age-related cognitive decline.

Main Methods:

• Systematic review of clinical trials involving Astaxanthin supplementation in older individuals.
• Analysis of reported cognitive function outcomes and safety data from human studies.

Main Results:

• Astaxanthin supplementation was generally well-tolerated, with no significant adverse effects reported in physical or laboratory examinations.
• A majority of trial subjects reported subjective and objective improvements in cognitive function, though statistical significance was not consistently achieved.
• Evidence suggests potential cognitive benefits of Astaxanthin in the elderly, including those with dementia.

Conclusions:

• Astaxanthin supplementation appears safe for older adults and may offer benefits for cognitive function.
• While direct mechanisms are unclear, Astaxanthin warrants consideration for managing age-related cognitive decline and dementia.
• Further research is needed to establish definitive efficacy and optimal use of Astaxanthin for cognitive health.