Related Experiment Video
Updated: Jun 20, 2025

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
Published on: September 20, 2017
Organization of hyaluronic acid molecules in solutions
Ferenc Horkay1, Peter J Basser1
1Section on Quantitative Imaging and Tissue Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 USA.
Abstract:
The organization of hyaluronic acid (HA) solutions was investigated by small angle neutron scattering (SANS). It was demonstrated that HA formed clusters greater than several hundred nanometers. The SANS response revealed a weak correlation peak, corresponding to ordering over a distance scale of about 80 nm. At higher wave vectors, the SANS response indicated the presence of rod-like structures. Addition of calcium ions only weakly affects the structure of the HA solution, but significantly reduces its osmotic pressure. The osmotic component of the SANS response is in good agreement with the intensity obtained from direct osmotic pressure measurements. The results are consistent with the rigid structure of the HA molecule.
More Related Videos
09:09Synthesis of PolyN-isopropylacrylamide Janus Microhydrogels for Anisotropic Thermo-responsiveness and Organophilic/Hydrophilic Loading Capability
Published on: February 27, 2016
06:54Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion
Published on: June 15, 2019
Related Concept Videos
Glycosaminoglycans
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...
Solubility
A solution is a homogeneous mixture composed of a solvent, the major component, and a solute, the minor component. The physical state of a solution—solid, liquid, or gas—is typically the same as that of the solvent. Solute concentrations are often described with qualitative terms such as dilute (of relatively low concentration) and concentrated (of relatively high concentration).
In a solution, the solute particles (molecules,...
Aqueous Solutions and Heats of Hydration
When ionic compounds dissolve in water, the ions in the solid separate and disperse uniformly throughout the solution because water molecules surround and solvate the ions, reducing the strong electrostatic forces between them. This process...
Entropy and Solvation
Polyprotic Acids
Solution Formation
This selective...