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An Uncommon Association: HLA-B27 Positivity in Conjunction With Pernicious Anemia - A Case Report and Literature

Auda H Auda1, Rami Atoot2, Mohammad Jurri1

  • 1Family Medicine, Hackensack Meridian Health Palisades Medical Center, North Bergen, USA.

Journal of Community Hospital Internal Medicine Perspectives
|July 22, 2024
PubMed

Insights

This case report details a rare instance of pernicious anemia causing peripheral neuropathy in a patient with HLA-B27 arthropathy. It highlights the need for thorough antibody screening in complex autoimmune cases.

Area of Science:

  • Immunology
  • Neurology
  • Genetics

Background:

  • Pernicious anemia (PA) results from Vitamin B12 deficiency due to autoimmune destruction of intrinsic factor.
  • Early PA diagnosis is difficult due to non-specific symptoms.
  • Human Leukocyte Antigen B27 (HLA-B27) is linked to various arthropathies.

Observation:

  • A case report of PA-induced peripheral neuropathy in a patient with concurrent HLA-B27 arthropathy.
  • This presentation is unusual as HLA-B27 is not typically associated with PA.

Findings:

  • The case demonstrates a complex interplay of autoimmune mechanisms.
  • Specific HLA haplotypes may influence the presentation of autoimmune disorders like PA.
  • Testing for anti-intrinsic factor and anti-parietal cell antibodies is vital.

Implications:

  • This case broadens the understanding of autoimmune disease associations.
  • It emphasizes tailored diagnostic and management strategies for PA patients, especially those with co-existing conditions.
  • Further research into HLA associations with PA is warranted.
Keywords:
Autoimmune disordersGastroenterologyGenetic predispositionHLA-B27Intrinsic factor antibodiesMacrocytic anemiaPeripheral neuropathyPernicious anemiaVitamin B12 deficiency

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