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Updated: Jun 20, 2025

Particle Agglutination Method for Poliovirus Identification
Published on: April 20, 2011
Naturally occurring anti-P1 with high thermal amplitude complicating ABO blood grouping
Shirin Ferdowsi1, Saeed Mohammadi1,2,3, Moharram Ahmadnezhad1
1Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran.
Abstract:
Anti-P1 is immunoglobulin M type and occurs naturally; it is often detected as a weak- and cold-reactive antibody. However, in rare cases, it is reactive at 37°C or shows hemolytic transfusion reactions. The presence of high thermal amplitude of anti-P1 cannot be ignored and requires cross-match compatible red blood cells for transfusion. In the present study, we report three cases with ABO discrepancy due to anti-P1 that was identified as a cold-reacting antibody with high thermal amplitude.
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