Jove
Visualize
Contact Us

Related Concept Videos

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving01:29

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

47
Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
47

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Conjoining of the TSH Receptor With the IGF-1 Receptor With Particular Attention to the Role of β1-Arrestin.

Endocrinology·2025
Same author

Mechanisms in Thyroid Eye Disease: The TSH Receptor Interacts Directly With the IGF-1 Receptor.

Endocrinology·2025
Same author

Molecular Dynamics (MD) Simulations Provide Insights into the Activation Mechanisms of 5-HT<sub>2A</sub> Receptors.

Molecules (Basel, Switzerland)·2024
Same author

TSH Receptor Oligomers Associated With the TSH Receptor Antibody Reactome.

Endocrinology·2024
Same author

Functional Water Channels Within the TSH Receptor: A New Paradigm for TSH Action With Disease Implications.

Endocrinology·2023
Same author

Substrate binding and inhibition of the anion exchanger 1 transporter.

Nature structural & molecular biology·2023
Same journal

Quantum simulation of alignment dependent differential cross sections in co-propagating molecular beams at cold collision energies.

The Journal of chemical physics·2026
Same journal

Non-additive ion effects on the coil-globule equilibrium of a generic polymer in aqueous salt solutions.

The Journal of chemical physics·2026
Same journal

Insights into the unexpected small reduction of the temperature of maximum density of water by lithium chloride addition.

The Journal of chemical physics·2026
Same journal

Optical frequency comb double-resonance spectroscopy of the 9030-9175 cm-1 states of ethylene.

The Journal of chemical physics·2026
Same journal

Time reversal breaking of colloidal particles in cells.

The Journal of chemical physics·2026
Same journal

Photodynamics of amino acids under UV excitation: Extraterrestrial amino acids.

The Journal of chemical physics·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 20, 2025

Methods for Presenting Real-world Objects Under Controlled Laboratory Conditions
06:54

Methods for Presenting Real-world Objects Under Controlled Laboratory Conditions

Published on: June 21, 2019

5.9K

MMC: A Monte Carlo laboratory.

Mihaly Mezei1

  • 1Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA and Thyroid Research Unit, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.

The Journal of Chemical Physics
|July 22, 2024
PubMed
Summary
This summary is machine-generated.

This Note details the unique features of the Molecular Mechanics Calculator (MMC) program, developed over 50 years. It highlights advanced sampling methods and novel analysis techniques for molecular simulations.

More Related Videos

Fabrication and Use of MicroEnvironment microArrays MEArrays
11:57

Fabrication and Use of MicroEnvironment microArrays MEArrays

Published on: October 11, 2012

10.0K
Scalable Nanohelices for Predictive Studies and Enhanced 3D Visualization
08:03

Scalable Nanohelices for Predictive Studies and Enhanced 3D Visualization

Published on: November 12, 2014

10.5K

Related Experiment Videos

Last Updated: Jun 20, 2025

Methods for Presenting Real-world Objects Under Controlled Laboratory Conditions
06:54

Methods for Presenting Real-world Objects Under Controlled Laboratory Conditions

Published on: June 21, 2019

5.9K
Fabrication and Use of MicroEnvironment microArrays MEArrays
11:57

Fabrication and Use of MicroEnvironment microArrays MEArrays

Published on: October 11, 2012

10.0K
Scalable Nanohelices for Predictive Studies and Enhanced 3D Visualization
08:03

Scalable Nanohelices for Predictive Studies and Enhanced 3D Visualization

Published on: November 12, 2014

10.5K

Area of Science:

  • Computational chemistry
  • Molecular modeling

Background:

  • The Molecular Mechanics Calculator (MMC) program has been developed over five decades.
  • Advanced computational tools are crucial for molecular simulations.

Purpose of the Study:

  • To describe the unique features of the MMC program.
  • To highlight the program's capabilities in sampling and analysis.

Main Methods:

  • Description of MMC program features.
  • Discussion of sampling techniques in three different ensembles.
  • Explanation of biased moves and non-conventional analysis.

Main Results:

  • MMC incorporates unique features developed over 50 years.
  • The program supports sampling in multiple ensembles.
  • Biased moves and novel analysis techniques are integrated.

Conclusions:

  • The MMC program offers advanced and unique functionalities for molecular simulations.
  • Its features facilitate sophisticated analysis and sampling strategies.