Related Experiment Video

Updated: Jun 20, 2025

In Vitro Analysis of E3 Ubiquitin Ligase Function
06:06

In Vitro Analysis of E3 Ubiquitin Ligase Function

Published on: May 14, 2021

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Role of MARCH E3 ubiquitin ligases in cancer development

Abhayananda Behera1, Deepanshi Sachan1, Ganesh Kumar Barik2

  • 1Department of Animal Biology, School of Life Sciences, University of Hyderabad, Hyderabad, 500046, India.

Cancer Metastasis Reviews
|July 22, 2024
PubMed

Insights

Membrane-associated RING-CH (MARCH) E3 ubiquitin ligases are crucial in immunity and metabolism. Their dysregulation impacts cancer, with some acting as oncogenes or tumor suppressors, highlighting their therapeutic potential.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Membrane-associated RING-CH (MARCH) E3 ubiquitin ligases are critical regulators of cellular processes.
  • Dysregulation of MARCH E3 ligases is implicated in various human cancers.
  • These ligases play multifaceted roles in immune regulation, inflammation, and metabolism.

Purpose of the Study:

  • To review the diverse functions of MARCH E3 ligases in different cancer types.
  • To elucidate the molecular mechanisms underlying their roles in cancer progression.
  • To highlight MARCH E3 ligases as potential therapeutic targets in oncology.

Main Methods:

  • Literature review of studies on MARCH E3 ligases and cancer.
  • Analysis of molecular mechanisms involving ubiquitination of oncogenes and tumor suppressors.
  • Examination of the role of MARCH5 in mitochondrial homeostasis within cancer cells.

Main Results:

  • MARCH E3 ligases exhibit context-dependent oncogenic or tumor suppressive activities.
  • They regulate key signaling pathways and proteins involved in cancer.
  • MARCH5 specifically influences mitochondrial dynamics in cancer cells.

Conclusions:

  • MARCH E3 ligases are pivotal in cancer development and progression.
  • Understanding their dual roles is essential for targeted cancer therapies.
  • MARCH E3 ligases, including MARCH5, represent promising therapeutic targets.
Keywords:
CancerMARCH E3 ligaseOncogeneRING-type E3 ubiquitin ligasesRegulationTherapeuticsTumor suppressorUbiquitination

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