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  11. Modeling Tumor Cell Dormancy In An Ex Vivo Liver Metastatic Niche

Modeling Tumor Cell Dormancy in an Ex Vivo Liver Metastatic Niche

Jacob C McDonald1, Amanda M Clark2,3,4,5,6

  • 1Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.

Methods in Molecular Biology (Clifton, N.J.)
|July 22, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Understanding tumor cell dormancy is key to preventing metastatic disease. The Legacy LiverChip® system models dormant cancer cells, offering insights into their biology and new therapeutic strategies.

Area of Science:

  • Oncology
  • Cell Biology
  • Biotechnology

Background:

  • Metastatic disease remains a significant challenge, with limited understanding of the mechanisms governing tumor cell dormancy.
  • Dormant tumor cells can survive in a foreign microenvironment, exhibit chemoresistance, and undergo reversible growth arrest, leading to disease recurrence.

Purpose of the Study:

  • To investigate the mechanisms that promote, maintain, and disrupt tumor cell dormancy.
  • To utilize an advanced ex vivo model to study dormant tumor cells and identify therapeutic strategies.

Main Methods:

  • Employing the Legacy LiverChip®, an all-human ex vivo hepatic microphysiological system.
  • Recreating metastatic disease and spontaneous tumor cell dormancy in a bioengineered environment.

Main Results:

Keywords:
MetastasisMicrometastasesMicrophysiological systemModel of tumor dormancy

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  • The LiverChip® system successfully mimics key traits of cellular dormancy, including survival, chemoresistance, and growth arrest.
  • The system provides critical insights into the biology of dormant tumor cells.

Conclusions:

  • The Legacy LiverChip® is a valuable tool for studying dormant tumor cells and their behavior.
  • This system can identify and evaluate novel therapeutic strategies targeting tumor cell dormancy and its associated toxicity.
Organ-on-a-chip