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Updated: Jun 20, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Deoxygenative alkynylation of amides via CO bond cleavage
Lan Chen1, Wei Zhou1, Jianwen Zhang1
1Department of Chemistry, Shanghai University, 99 Shangda Road, Shanghai 200444, China. liuchengwei@shu.edu.cn.
Abstract:
A novel deoxygenative alkynylation of amides promoted by a synergistic action of a divalent rare-earth element and a transition metal has been developed. In this method, α-alkynyl substituted amines are synthesized from unactivated amides and alkynes in a single transformation. Broad substrate scope and excellent selectivity for CO cleavage has been demonstrated. This approach represents a general method for the construction of versatile α-alkynyl substituted amines from unactivated amide bonds.
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