Functional connectivity associations with menstrual pain characteristics in adolescents: an investigation of the triple network model
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View abstract on PubMed
Summary
This summary is machine-generated.Adolescent menstrual pain is linked to altered brain network connectivity, specifically within the triple network model (TNM). These findings reveal how brain networks process pain differently in young individuals with varying pain levels.
Area Of Science
- Neuroscience
- Pain Research
- Adolescent Health
Background
- Menstrual pain is common in adolescents but its underlying neural mechanisms are not fully understood.
- Previous neuroimaging studies focused on adult group comparisons, limiting insights into adolescent pain processing.
- The triple network model (TNM) offers a framework to explore brain network interactions in pain.
Purpose Of The Study
- To investigate the role of the TNM in adolescent girls with varying menstrual pain severity.
- To examine associations between menstrual pain characteristics and functional brain connectivity.
- To identify neural correlates of menstrual pain in a young female population.
Main Methods
- Resting-state functional magnetic resonance imaging (fMRI) was used in 100 adolescent girls (ages 13-19).
- Participants rated menstrual pain severity, interference, and cumulative exposure.
- Analyses examined functional connectivity within and between major brain networks, controlling for age and gynecological age.
Main Results
- Menstrual pain severity correlated with increased connectivity between the cingulo-opercular salience network (cSN) and sensory/limbic regions, and within the left central executive network (CEN).
- Menstrual pain interference showed positive associations with cSN connectivity and left CEN connectivity, but negative associations with right CEN connectivity.
- Cumulative menstrual pain exposure was negatively associated with default mode network connectivity.
Conclusions
- The TNM plays a significant role in the characteristics of adolescent menstrual pain.
- Altered functional connectivity within and between brain networks is evident in adolescents with varying menstrual pain.
- These findings highlight the importance of studying adolescent pain processing using network-based approaches.
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