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Published on: December 19, 2020
[Prevalence and prognostic role of thoracic lymphadenopathy in Covid-19]
Insights
Thoracic lymphadenopathy, a common finding in COVID-19 patients, significantly increases the risk of mortality. This meta-analysis confirms its role as an important prognostic indicator in coronavirus disease 2019.
Area of Science:
- Medical Imaging
- Infectious Diseases
- Public Health
Background:
- The COVID-19 pandemic poses a significant global health threat.
- The prognostic value of thoracic lymphadenopathy in COVID-19 patients remains uncertain.
Purpose of the Study:
- To conduct a meta-analysis examining the prognostic role of thoracic lymphadenopathy in predicting 30-day mortality among COVID-19 patients.
Main Methods:
- A systematic literature search of MEDLINE, Cochrane, and SCOPUS databases was performed up to June 2021.
- Twenty-one studies comprising 4621 patients were included, with study quality assessed using the Newcastle-Ottawa Scale.
- Meta-analysis was conducted using RevMan 5.3 with random-effect models.
Main Results:
- The pooled prevalence of thoracic lymphadenopathy in COVID-19 patients was 16.7%.
- Hospital mortality was higher in patients with thoracic lymphadenopathy (34.7%) compared to those without (20.0%).
- Thoracic lymphadenopathy was associated with a 2.13-fold increased odds of mortality (p < 0.001).
Conclusions:
- Thoracic lymphadenopathy is present in 16.7% of COVID-19 cases.
- The presence of thoracic lymphadenopathy is linked to a nearly twofold increased risk of hospital mortality.
- Thoracic lymphadenopathy serves as a significant prognostic factor in COVID-19 patients.
Purpose:
The prevalent coronavirus disease 2019 (COVID-19) pandemic has spread throughout the world and is considered a serious threat to global health. The prognostic role of thoracic lymphadenopathy in COVID-19 is unclear. The aim of the present meta-analysis was to analyze the prognostic role of thoracic lymphadenopathy for the prediction of 30-day mortality in patients with COVID-19.
Materials And Methods:
The MEDLINE library, Cochrane, and SCOPUS databases were screened for associations between CT-defined features and mortality in COVID-19 patients up to June 2021. In total, 21 studies were included in the present analysis. The quality of the included studies was assessed by the Newcastle-Ottawa Scale. The meta-analysis was performed using RevMan 5.3. Heterogeneity was calculated by means of the inconsistency index I2. DerSimonian and Laird random-effect models with inverse variance weights were performed without any further correction.
Results:
The included studies comprised 4621 patients. The prevalence of thoracic lymphadenopathy varied between 1 % and 73.4 %. The pooled prevalence was 16.7 %, 95 % CI = (15.6 %; 17.8 %). The hospital mortality was higher in patients with thoracic lymphadenopathy (34.7 %) than in patients without (20.0 %). The pooled odds ratio for the influence of thoracic lymphadenopathy on mortality was 2.13 (95 % CI = [1.80-2.52], p < 0.001).
Conclusion:
The prevalence of thoracic lymphadenopathy in COVID-19 is 16.7 %. The presence of thoracic lymphadenopathy is associated with an approximately twofold increase in the risk for hospital mortality in COVID-19.
Key Points:
· The prevalence of lymphadenopathy in COVID-19 is 16.7 %.. · Patients with lymphadenopathy in COVID-19 have a higher risk of mortality during hospitalization.. · Lymphadenopathy nearly doubles mortality and plays an important prognostic role..
Citation Format:
· Bucher AM, Sieren M, Meinel F et al. Prevalence and prognostic role of thoracic lymphadenopathy in Covid-19. Rofo 2025; 197: 163 - 171.
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