[Prevalence and prognostic role of thoracic lymphadenopathy in Covid-19]

,

    Rofo : Fortschritte Auf Dem Gebiete Der Rontgenstrahlen Und Der Nuklearmedizin
    |July 22, 2024
    PubMed

    Insights

    Thoracic lymphadenopathy, a common finding in COVID-19 patients, significantly increases the risk of mortality. This meta-analysis confirms its role as an important prognostic indicator in coronavirus disease 2019.

    Area of Science:

    • Medical Imaging
    • Infectious Diseases
    • Public Health

    Background:

    • The COVID-19 pandemic poses a significant global health threat.
    • The prognostic value of thoracic lymphadenopathy in COVID-19 patients remains uncertain.

    Purpose of the Study:

    • To conduct a meta-analysis examining the prognostic role of thoracic lymphadenopathy in predicting 30-day mortality among COVID-19 patients.

    Main Methods:

    • A systematic literature search of MEDLINE, Cochrane, and SCOPUS databases was performed up to June 2021.
    • Twenty-one studies comprising 4621 patients were included, with study quality assessed using the Newcastle-Ottawa Scale.
    • Meta-analysis was conducted using RevMan 5.3 with random-effect models.

    Main Results:

    • The pooled prevalence of thoracic lymphadenopathy in COVID-19 patients was 16.7%.
    • Hospital mortality was higher in patients with thoracic lymphadenopathy (34.7%) compared to those without (20.0%).
    • Thoracic lymphadenopathy was associated with a 2.13-fold increased odds of mortality (p < 0.001).

    Conclusions:

    • Thoracic lymphadenopathy is present in 16.7% of COVID-19 cases.
    • The presence of thoracic lymphadenopathy is linked to a nearly twofold increased risk of hospital mortality.
    • Thoracic lymphadenopathy serves as a significant prognostic factor in COVID-19 patients.
    Abstract

    Related Concept Videos

    COPD: Pathogenesis and Clinical Features01:20

    COPD: Pathogenesis and Clinical Features

    Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
    The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
    252
    Secondary Lymphoid Organs01:15

    Secondary Lymphoid Organs

    Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
    The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
    1.4K
    Primary Lymphoid Organs01:16

    Primary Lymphoid Organs

    Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
    The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
    1.5K
    Pleural Effusion II: Symptoms and Management01:28

    Pleural Effusion II: Symptoms and Management

    Pleural Effusion Overview
    A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
    Clinical Manifestations:
    162
    Pneumothorax-II01:27

    Pneumothorax-II

    Pneumothorax is a medical condition defined by the buildup of air in the pleural space between the lungs and the chest wall. This accumulation of air can lead to partial or complete lung collapse, resulting in a range of clinical manifestations. Understanding the clinical presentation and effective management strategies is crucial for healthcare professionals in providing timely and appropriate care to individuals with pneumothorax.
    Clinical Manifestations:
    135
    Pneumonia II: Pathophysiology01:29

    Pneumonia II: Pathophysiology

    The pathophysiology of pneumonia involves the following steps:
    240