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Related Concept Videos

Regulation of Food Intake01:30

Regulation of Food Intake

213
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
213

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Fat Preference: A Novel Model of Eating Behavior in Rats
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Hippocampus Oxytocin Signaling Promotes Prosocial Eating in Rats.

Jessica J Rea1, Clarissa M Liu1, Anna M R Hayes2

  • 1Human and Evolutionary Biology Section, Department of Biological Sciences, Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, California; Neuroscience Graduate Program, University of Southern California, Los Angeles, California.

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Summary

Oxytocin signaling in the dorsal hippocampus promotes eating in social contexts, influencing food preference learning and social memory. This highlights a novel link between oxytocin, eating, and social behaviors.

Keywords:
EatingHypothalamusNeuropeptidesObesityRewardSocial facilitation of eating

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Area of Science:

  • Neuroscience
  • Behavioral Endocrinology
  • Neurobiology

Background:

  • Oxytocin (OT) is a neuropeptide regulating social behavior and food intake.
  • The interplay between OT's roles in social behavior and eating is not well understood.
  • The dorsal hippocampus (HPCd) is a potential site for the overlap of these functions.

Purpose of the Study:

  • To investigate the role of oxytocin signaling in the dorsal hippocampus (HPCd) in integrating eating and social behaviors.
  • To determine if HPCd OT signaling modulates social facilitation of eating and social transmission of food preference.

Main Methods:

  • Utilized gain- and loss-of-function strategies for HPCd OT signaling in male Sprague Dawley rats.
  • Assessed food intake under isolated and social conditions (familiar/unfamiliar conspecifics).
  • Evaluated the role of HPCd OT in social transmission of food preference, sociality, and social recognition memory.

Main Results:

  • HPCd OT administration increased food intake specifically in the presence of a familiar conspecific.
  • Knockdown of HPCd OT receptor eliminated the social facilitation of eating by familiar conspecifics.
  • HPCd OT receptor knockdown impaired social transmission of food preference and social recognition memory.

Conclusions:

  • Endogenous HPCd OT signaling is a novel substrate integrating eating and social behaviors.
  • OT in the HPCd plays a critical role in the social facilitation of eating.
  • HPCd OT signaling is essential for social transmission of food preference and social recognition memory.