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Reference values for biochemical tests during pregnancy: Analysis of the PRECAREbio Cohort and correlation with
J Phelippeau1, E Azria2, P F Ceccaldi1
1Department of Obstetrics and Gynecology, Bichat-Beaujon Hospital, University Hospital Department (DHU) Risks in Pregnancy, Paris Diderot University, Paris, France.
Insights
This study established normal biochemical parameter values during pregnancy in Paris. Maternal social deprivation did not influence these essential pregnancy health markers.
Area of Science:
- Biochemistry
- Obstetrics
- Public Health
Background:
- Pregnancy involves significant physiological biochemical changes.
- Understanding normal biochemical ranges is crucial for maternal health monitoring.
- Maternal socioeconomic status can impact health outcomes.
Purpose of the Study:
- To establish normal biochemical parameter values during pregnancy in Paris.
- To analyze biochemical changes throughout gestation.
- To investigate the impact of maternal social deprivation on these parameters.
Main Methods:
- Prospective cohort study (PreCAREbio) of pregnant women in Paris.
- Longitudinal assessment of 26 biochemical parameters.
- Analysis of data from 386 women with 1733 blood samples.
Main Results:
- Normal reference values for 26 biochemical markers during pregnancy were established.
- Biochemical marker concentrations remained stable throughout pregnancy.
- No significant differences were observed in biochemical markers between socially deprived and non-deprived women.
Conclusions:
- Established normal biochemical reference ranges for pregnant women in Paris.
- Maternal social deprivation did not demonstrate a significant influence on the studied biochemical markers.
Objective:
To establish normal current values of various biochemical parameters during pregnancy in the northern area of Paris (France) in a subgroup from the PreCARE cohort and to study their changes according to the term of pregnancy, and to determine the influence of maternal precarity.
Design:
The PreCAREbio cohort of pregnant women was defined in the PreCARE study, a multicenter cohort study.
Setting:
Participants completed detailed questionnaires at enrolment and immediately postpartum. Data were collected prospectively. 26 biochemical parameters were longitudinally assessed.
Population:
All women registered to deliver or who delivered at one of the four participating university hospitals in Paris between October 2010 and November 2011 were eligible for study inclusion (n = 10,419).
Methods:
We studied 26 biochemical markers during pregnancy and the influence of maternal social deprivation.
Main Outcome Measures:
Baseline values for 26 biochemical markers and their changes according to the term of pregnancy, and the influence of maternal social deprivation on these biochemical markers.
Results:
386 patients with 1733 blood samples recruited in one of the four centers in the PreCARE cohort were included. Baseline concentrations (median, 2.5th and 97.5th percentile) for each marker and did not differ at the different time points. Mean concentrations of each biochemical marker did not differ between socially deprived women and non-socially deprived women.
Conclusions:
We have established normal values for 26 biochemical parameters during pregnancy. We have also shown no difference in these values between socially deprived and non- socially deprived women.
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