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Prospecting Microbial Strains for Bioremediation and Probiotics Development for Metaorganism Research and Preservation

Prospecting Microbial Strains for Bioremediation and Probiotics Development for Metaorganism Research and Preservation

Published on: October 31, 2019

Precision probiotics supplement strategy in aging population based on gut microbiome composition.

Yi-Fang Chuang^1,2,3, Kang-Chen Fan¹, Yin-Yuan Su⁴

¹School of Medicine, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong St. Beitou Dist., Taipei City 112304, Taiwan.

Briefings in Bioinformatics

|July 22, 2024

Summary

Personalized probiotic supplements show promise for older adults by targeting specific gut bacteria. Tailoring probiotics to individual gut microbiota may help manage age-related diseases and improve health outcomes.

Keywords:

consensus clustering gut microbiome metagenomics non-negative matrix factorization older adults precision probiotics

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Published on: July 31, 2019

Area of Science:

Gerontology
Microbiology
Immunology

Background:

Age-related chronic diseases necessitate novel management strategies.
The gut microbiota's composition and function change significantly with aging.
These aging-related alterations in gut microbiota can impact health and disease progression.

Purpose of the Study:

To investigate the potential of personalized probiotic supplements in older adults.
To analyze gut microbiota composition and its association with health parameters in aging individuals.
To identify specific microbial signatures that could be targeted by probiotics.

Main Methods:

Metagenomic sequencing was employed to analyze the gut microbiota of 297 older adults.
Microbial signatures, including Lactobacillus and Bifidobacterium, were identified.
Associations between microbial profiles and population characteristics, cognitive function, and neuroimaging were explored.

Main Results:

Distinctive Lactobacillus and Bifidobacterium patterns were observed in the gut microbiota of older adults.
Probiotic patterns correlated with demographic factors, microbial diversity, cognitive status, and neuroimaging findings.
These findings suggest a basis for personalized probiotic interventions.

Conclusions:

Tailored probiotic supplements, matched to individual gut microbiota profiles, represent a potential strategy for addressing age-related decline.
The study provides evidence supporting the use of probiotics in older populations for targeted health benefits.
Further longitudinal research with larger cohorts is needed to confirm the efficacy of precision probiotics in aging individuals.