Drug exposure and risk factors of maculopathy in tamoxifen users
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View abstract on PubMed
Summary
This summary is machine-generated.Tamoxifen use for breast cancer may cause macular disease, with risk increasing with age and cumulative dose. Age, dose, and liver disease are key risk factors for tamoxifen maculopathy.
Area Of Science
- Ophthalmology
- Oncology
- Pharmacology
Background
- Tamoxifen is a vital treatment for hormone receptor-positive breast cancer, reducing recurrence and mortality.
- Ocular complications, specifically maculopathy, are a growing concern with tamoxifen therapy.
- Understanding risk factors for tamoxifen-induced maculopathy is crucial for patient safety.
Purpose Of The Study
- To investigate the incidence and risk factors of various macular conditions in tamoxifen users.
- To analyze the association between drug exposure, demographics, and systemic diseases with macular conditions.
- To inform clinical guidelines for screening and managing tamoxifen maculopathy.
Main Methods
- Analysis of a nationwide cohort of 14,267 tamoxifen users from South Korea's health insurance database.
- Stratification of macular disease incidence by age and cumulative tamoxifen dosage.
- Logistic regression and Cox proportional hazard models to identify risk factors and predictive characteristics.
Main Results
- Cumulative incidences: overall macular diseases (26.4%), other maculopathy (11.4%), macular edema (6.5%).
- Incidence of macular conditions increased with age and cumulative tamoxifen dose.
- Age, cumulative dose, and liver diseases were significantly associated with overall macular diseases and maculopathy (P < 0.05).
Conclusions
- Tamoxifen-induced maculopathy is a significant concern for physicians and ophthalmologists.
- Age, cumulative tamoxifen dose, and liver disease are key risk factors.
- Findings support evidence-based screening guidelines for tamoxifen maculopathy, considering individual patient factors.
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