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Endothelial microRNAs in INOCA patients with diabetes mellitus
Marco Ferrone1, Michele Ciccarelli2, Fahimeh Varzideh3
1Casa di Cura "Montevergine", Mercogliano, Avellino, Italy.
Insights
This study identifies specific microRNAs (miRNAs) as potential biomarkers for endothelial dysfunction in patients with ischemia with non-obstructive coronary artery (INOCA), especially those with diabetes mellitus (DM). These findings aid in predicting and monitoring cardiovascular complications.
Area of Science:
- Cardiovascular Research
- Molecular Biology
- Endocrinology
Background:
- Ischemia with non-obstructive coronary artery (INOCA) is a prevalent condition linked to endothelial dysfunction and poor outcomes.
- Diabetes mellitus (DM) exacerbates INOCA by worsening endothelial impairment and coronary microvascular dysfunction.
- MicroRNAs (miRNAs) are implicated in endothelial function and cardiovascular diseases, but their role in INOCA remains understudied.
Purpose of the Study:
- To investigate circulating miRNA profiles in INOCA patients with and without DM.
- To identify specific miRNAs associated with endothelial dysfunction in the context of INOCA and DM.
- To explore the potential of miRNAs as biomarkers for INOCA patients with DM.
Main Methods:
- Analysis of circulating miRNA expression using quantitative reverse transcription polymerase chain reaction (RT-qPCR).
- Study cohort comprised consecutive INOCA patients undergoing percutaneous coronary intervention.
- Comparison of miRNA expression between INOCA patients with and without DM.
Main Results:
- Significant dysregulation of miR-363-5p and miR-92a-3p was observed in INOCA patients with DM compared to those without DM.
- These specific miRNAs are implicated in the regulation of endothelial function.
- The findings suggest a differential miRNA expression pattern related to diabetes status in INOCA.
Conclusions:
- miR-363-5p and miR-92a-3p may serve as valuable biomarkers for endothelial dysfunction in INOCA patients with DM.
- These miRNAs could aid in the prediction and monitoring of cardiovascular complications in this patient group.
- Further research is warranted to validate these miRNA biomarkers and explore therapeutic strategies.
Abstract:
Ischemia with non-obstructive coronary artery (INOCA) is a common cause of hospital admissions, leading to negative outcomes and reduced quality of life. Central to its pathophysiology is endothelial dysfunction, which contributes to myocardial ischemia despite the absence of significant coronary artery blockage. Addressing endothelial dysfunction is essential in managing INOCA to alleviate symptoms and prevent cardiovascular events. Recent studies have identified diabetes mellitus (DM) as a significant factor exacerbating INOCA complications by promoting endothelial impairment and coronary microvascular dysfunction. MicroRNAs (miRNAs) have emerged as potential biomarkers and therapeutic targets in various biological processes, including endothelial dysfunction and cardiovascular diseases. However, research on miRNA biomarkers in INOCA patients is sparse. In this study, we examined a panel of circulating miRNAs involved in the regulation of endothelial function in INOCA patients with and without DM. We analyzed miRNA expression using RT-qPCR in a cohort of consecutive INOCA patients undergoing percutaneous coronary intervention. We detected a significant dysregulation of miR-363-5p and miR-92a-3p in INOCA patients with DM compared to those without DM, indicating their role as biomarkers for predicting and monitoring endothelial dysfunction in INOCA patients with DM.
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