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Related Concept Videos

Inflammatory Response01:28

Inflammatory Response

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An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
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Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
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Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
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Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

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Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
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Nanotechnology-Mediated Immunomodulation Strategy for Inflammation Resolution.

Ying Li1, Wen Liu1, Yuanchao Wang1

  • 1School of Chemical Engineering and Technology, Tianjin University, Yaguan Road 135, Tianjin, 300350, P. R. China.

Advanced Healthcare Materials
|July 23, 2024
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Nanomedicines offer a novel approach to managing inflammation by modulating immune responses. This nanotechnology-mediated immunomodulation presents a promising new strategy for treating inflammatory diseases.

Keywords:
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Area of Science:

  • Biomedical Engineering
  • Immunology
  • Nanotechnology

Background:

  • Inflammation is a hallmark of many diseases, crucial for homeostasis but leading to damage.
  • Current anti-inflammatory treatments like corticosteroids offer only temporary relief.
  • Immunomodulatory strategies are emerging as effective long-term solutions.

Purpose of the Study:

  • To review the pathophysiology of inflammation and current therapeutic strategies.
  • To focus on nanomedicines for modulating inflammatory pathways, cells, and oxidative stress.
  • To discuss the challenges and opportunities of nanomaterials in inflammation treatment.

Main Methods:

  • Literature review of inflammation pathophysiology and therapeutic strategies.
  • Analysis of nanomedicine applications in modulating inflammatory processes.
  • Discussion of nanotechnology-based immunomodulation.

Main Results:

  • Nanosystems provide a versatile platform for immunomodulation due to their biocompatibility and multifunctionality.
  • Nanomedicines can target inflammatory signaling pathways, cells, and oxidative stress.
  • Nanotechnology offers advanced strategies for inflammation targeting.

Conclusions:

  • Nanotechnology-mediated immunomodulation represents a significant advancement in inflammation therapy.
  • Advanced nanosystems are key to developing novel and effective treatments for inflammatory diseases.
  • Further research into nanomaterials will unlock new opportunities for managing inflammation.