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The disordering effect of SARMs on a biomembrane model
Alma Jessica Díaz-Salazar1, Arián Espinosa-Roa2, Enrique Saldívar-Guerra3
1Laboratorio de Bio-fisicoquímica. Departamento de Fisicoquímica, Facultad de Química, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico. jessica.diaz@quimica.unam.mx.
Physical Chemistry Chemical Physics : PCCP
|July 23, 2024
Summary
Selective androgen receptor modulators (SARMs) interact with lipid membranes, altering their properties. This study investigates SARMs
Area of Science:
- Biophysics
- Pharmacology
- Materials Science
Background:
- Selective androgen receptor modulators (SARMs) show therapeutic potential but have safety concerns.
- SARMs' hydrophobic nature suggests interaction with lipid membranes.
- The biophysical effects of SARMs on cell membranes are not well understood.
Purpose of the Study:
- To investigate the interaction of specific SARMs (ostarine, ligandrol, andarine, cardarine) with a lipid biomembrane model.
- To elucidate the physical and chemical changes induced by SARMs in lipid bilayers.
- To understand the driving forces behind SARMs-lipid membrane interactions.
Main Methods:
- Differential scanning calorimetry (DSC)
- Dynamic light scattering (DLS)
- Attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR)
- Density functional theory (DFT) calculations
Main Results:
- Ostarine, ligandrol, andarine, and cardarine strongly interact with a DMPC lipid biomembrane model.
- SARMs incorporate into both polar and hydrophobic regions of the lipid bilayer.
- DFT calculations revealed potential electrostatic interactions between SARMs and phospholipids.
Conclusions:
- SARMs significantly alter the thermodynamic properties of lipid biomembranes.
- Understanding SARMs' membrane interactions is crucial for their safe application in medicine and sport.
- This research provides biophysical insights into SARMs' effects on biological systems.
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