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[Two new glycosides from Hypericum elatoides].

Zi-Xuan Wang1, Zhen An1, Han-Wu Liu1

  • 1Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy,Northwest A & F University Yangling 712100, China.

Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica
|July 23, 2024
PubMed
Summary
This summary is machine-generated.

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Two new glycosides, hyperelatosides G and H, were discovered in Hypericum elatoides. Quercetin-3-O-β-D-glucopyranoside showed anti-neuroinflammatory activity, while other compounds exhibited neuroprotective effects.

Area of Science:

  • Phytochemistry
  • Natural Products Chemistry
  • Pharmacognosy

Context:

  • Hypericum elatoides, a medicinal plant, is traditionally used for various ailments.
  • The chemical constituents of H. elatoides have not been fully elucidated.
  • Understanding the phytochemical profile is crucial for identifying bioactive compounds.

Purpose:

  • To isolate and identify chemical constituents from the methanol extract of Hypericum elatoides aerial parts.
  • To characterize novel compounds and report new natural product discoveries.
  • To evaluate the biological activities of the isolated compounds, focusing on neuroinflammation and neuroprotection.

Summary:

  • Column chromatography using silica gel, C18, and Sephadex LH-20 was used to separate compounds from H. elatoides methanol extract.
Keywords:
H. elatoidesHypericumchemical constituentshyperelatoside Ghyperelatoside H

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  • Twenty-one compounds were identified, including two new glycosides named hyperelatosides G and H (compounds 1 and 2).
  • Compounds 3-5, 7-9, 17, 20-21 were new to the Hypericum genus, and the rest were new to H. elatoides. Compound 11 (quercetin-3-O-β-D-glucopyranoside) demonstrated significant anti-neuroinflammatory activity.
  • Compounds 1, 3, and 19 showed notable neuroprotective effects.

    • Impact:

    • This study expands the knowledge of the phytochemical diversity within the Hypericum genus.
    • The discovery of novel glycosides and the identification of bioactive compounds contribute to the potential development of new therapeutic agents.
    • The findings support the traditional use of H. elatoides and provide a basis for further pharmacological investigations.