[Chemical constituents from Cinnamomi Ramulus decoction]

Area of Science:

• Phytochemistry
• Natural Product Chemistry
• Pharmacology

Context:

• Cinnamomi Ramulus is a traditional medicinal herb.
• Chemical constituents of Cinnamomi Ramulus are of interest for their potential bioactivities.
• Isolation and characterization of compounds from medicinal plants are crucial for drug discovery.

Purpose:

• To isolate and identify chemical compounds from Cinnamomi Ramulus decoction.
• To investigate the anti-inflammatory and cytotoxic activities of isolated compounds, particularly a novel bisabolene sesquiterpene.

Summary:

• Six compounds were isolated from Cinnamomi Ramulus using chromatography and HPLC: 4,5,10,11-tetrahydroxybisabol-7-ene (1), 4,5,10,11-tetrahydroxybisabolin (2), 1-phenyl-1,2,3-glycerol (3), (+)-lyoniresinol (4), benzoic acid (5), and decumbic acid (6).
• Compound 1 is a new bisabolene-type sesquiterpene. Compounds 2 and 3 were isolated from this source for the first time.
• Compound 2 demonstrated a 32.9% inhibition of nitric oxide (NO) at 40 μmol·L⁻¹ and a 14.5% proliferation inhibition of PANC-1 cells at 20 μmol·L⁻¹, though overall activity was not significant.

Impact:

• Identifies a new sesquiterpene and two compounds new to Cinnamomi Ramulus.
• Provides preliminary data on the anti-inflammatory and anti-pancreatic cancer cell activity of a bisabolene sesquiterpene.
• Contributes to the understanding of Cinnamomi Ramulus phytochemistry and potential therapeutic applications.