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[Research progress in targeting DNA G-quadruplexes using natural products].

Zhi-Yuan Chen1, Rong-Shuang Cheng1, Wubulikasimu Ayixia1

  • 1Jiangsu Key Laboratory of Bioactive Natural Product Research, State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University Nanjing 211198, China.

Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica
|July 23, 2024
PubMed
Summary

Natural products are being developed as anticancer drugs targeting DNA G-quadruplexes (G4s), which are crucial in cancer development. This review highlights natural small molecules targeting G4s and their potential for novel antitumor medications.

Keywords:
DNA G-quadruplexantitumornatural productsoncogene

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pharmacology

Background:

  • DNA G-quadruplexes (G4s) are four-stranded DNA structures found in oncogenes and telomeres, implicated in cancer progression.
  • G4 structures are recognized as promising therapeutic targets for anticancer drug development.

Purpose of the Study:

  • To review the progress in discovering natural small molecules that target DNA G-quadruplexes.
  • To summarize the binding mechanisms of these natural products with G4s.
  • To discuss the prospects and challenges in developing G4-targeting drugs.

Main Methods:

  • Literature review of research on natural products targeting DNA G-quadruplexes.
  • Analysis of studies detailing G4-ligand interactions and binding mechanisms.
  • Synthesis of information on specific G4 targets (e.g., MYC-G4, KRAS-G4, telomeric G4).

Main Results:

  • Numerous natural products have been identified as effective binders of various DNA G-quadruplex structures.
  • Specific G4 targets like MYC-G4, KRAS-G4, and telomeric G4 are validated targets for natural product intervention.
  • Established binding mechanisms provide a foundation for rational drug design.

Conclusions:

  • Natural products represent a rich source for developing novel anticancer therapeutics targeting DNA G-quadruplexes.
  • Further research into G4-natural product interactions can accelerate the development of new antitumor drugs.
  • Overcoming challenges in drug development will be key to realizing the therapeutic potential of G4-targeting natural products.