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Related Concept Videos

Detailed Structure and Function of Lymph Nodes01:23

Detailed Structure and Function of Lymph Nodes

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Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
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Quantification of Tumor Cell Adhesion in Lymph Node Cryosections
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Factors affecting lymph node yield and density in neck dissection.

Pelle Hanberg1,2,3, Trine Tramm2,4, Arunas Pikelis1

  • 1Department of Otorhinolaryngology, Head and Neck Surgery, Aarhus University Hospital, Aarhus, Denmark.

Acta Oto-Laryngologica
|July 23, 2024
PubMed
Summary
This summary is machine-generated.

Higher lymph node yield in neck dissections is linked to better survival. This study found body weight positively impacts yield, while prior radiotherapy negatively affects it, influencing neck dissection quality assessment.

Keywords:
Lymph node yieldcancermalignancymetastasisneck dissectionoral cavity

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Head and Neck Cancer Research

Background:

  • Neck dissection lymph node yield is a critical indicator of surgical quality and patient outcomes.
  • Studies suggest a threshold of 16-18 lymph nodes for improved survival in neck dissections.

Purpose of the Study:

  • To identify factors influencing lymph node yield and density in oral cavity cancer patients.
  • To analyze predictors of lymph node recovery during elective neck dissection (levels 1-3).

Main Methods:

  • A prospective, population-based cohort study of 221 oral cavity cancer patients undergoing neck dissection (levels 1-3) from 2018-2022.
  • Univariate and multivariate analyses were employed to determine factors associated with lymph node yield and density.

Main Results:

  • The mean lymph node yield was 19 nodes, with a mean density of 0.12.
  • Multivariate analysis revealed a positive correlation between increasing body weight and lymph node yield (p=0.034).
  • Previous radiotherapy showed a negative correlation with lymph node yield (p=0.006).

Conclusions:

  • Body weight and prior radiotherapy are significant factors influencing lymph node yield in neck dissections for oral cavity cancer.
  • These findings are crucial for accurately interpreting lymph node yield as a measure of surgical quality and prognostic indicator.