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ABO-incompatible kidney transplantation using immunoadsorption columns: First experiences in South Africa
1Division of Nephrology and Hypertension, Department of Medicine, Faculty of Health Sciences, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa. zunaid.barday@uct.ac.za.
Summary
ABO-incompatible kidney transplants offer a vital option for dialysis patients. This study shows Glycosorb ABO immunoadsorption (IA) successfully enabled these transplants in South Africa.
Area of Science:
- Nephrology
- Transplantation Immunology
Background:
- Chronic kidney disease (CKD) patients requiring dialysis often lack compatible donors.
- ABO-incompatible kidney transplantation presents an alternative for these patients.
Purpose of the Study:
- To report the initial outcomes of ABO-incompatible living-donor kidney transplants using Glycosorb ABO immunoadsorption (IA) columns.
- To document the first application of this technique in Africa.
Main Methods:
- Three patients underwent ABO-incompatible kidney transplantation.
- Patients received rituximab approximately one month prior to transplant.
- Glycosorb ABO immunoadsorption (IA) columns were used, with 1-4 sessions per patient.
Main Results:
- All patients achieved the target antibody titer of 1:4 before transplantation.
- Only one patient required post-transplant IA.
- No clinical rejection occurred, and all patients maintained good graft function.
Conclusions:
- Glycosorb ABO IA is effective for ABO-incompatible kidney transplantation.
- This technique facilitates successful living-donor kidney transplants in a South African context.
