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Diagnosing Pulmonary Tuberculosis with the Xpert MTB/RIF Test
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Missed rifampicin and isoniazid resistance by commercial molecular assays
L Richards1, F Ismail2, J Nel3
1Division of Infectious Diseases, Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. lauren.richards@wits.ac.za.
Abstract:
Drug-resistant tuberculosis (TB) has poor outcomes unless resistance is detected early, ideally by commercially available molecular tests. We present a case of occult multidrug-resistant TB where both rifampicin and isoniazid resistance were missed by molecular testing and were only identified by phenotypic testing.

