A novel prognostic index for extranodal natural killer/T-cell lymphoma in the era of pegaspargase/L-asparaginase

Ziyuan Shen ^1,2, Xudong Zhang ³, Yujie Li ¹

¹Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221006, China.
²Department of Epidemiology & Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, 230032, China.
³Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.
⁴Department of Hematology, The Affiliated Hospital of Jining Medical University, Jining, Shandong, 272000, China.
⁵Department of Hematology, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, China.
⁶Department of Hematology, Tai'an Central Hospital, Tai'an, Shandong, 271000, China.
⁷Department of Hematology, The First People's Hospital of Lianyungang, Lianyungang, Jiangsu, 222061, China.
⁸Department of Hematology, The General Hospital of Wanbei Coal-Electric Group, Suzhou, Anhui, 234011, China.
⁹Department of Hematology, Yancheng First People's Hospital, Yancheng, Jiangsu, 224001, China.
¹⁰Department of Hematology, The First People's Hospital of Huai'an, Huai'an, Jiangsu, 223300, China.
¹¹Department of Pathology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221006, China.
¹²Department of Hematology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100005, China.
¹³Blood Diseases Institute, Xuzhou Medical University, Xuzhou, Jiangsu, 221006, China.
¹⁴Key Laboratory of Bone Marrow Stem Cell, Xuzhou, Jiangsu, 221006, China.

⁰Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221006, China.

Future Oncology +

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July 23, 2024

View abstract on PubMed

Summary

A new prognostic index, the Huaihai Lymphoma Working Group-Natural killer/T-cell Lymphoma prognostic index (NPI), was developed for extranodal natural killer/T-cell lymphoma (ENKTL) patients. This system effectively stratifies risk and predicts survival in the pegaspargase/L-asparaginase treatment era.

Area Of Science

Hematology
Oncology
Clinical Research

Background

Extranodal natural killer/T-cell lymphoma (ENKTL) is an aggressive non-Hodgkin lymphoma.
Accurate prognostic systems are crucial for guiding treatment decisions in ENKTL patients, especially with modern therapies like pegaspargase/L-asparaginase.

Purpose Of The Study

To develop and validate a novel prognostic index for extranodal natural killer/T-cell lymphoma (ENKTL) patients.
To identify independent prognostic factors in ENKTL patients treated with pegaspargase/L-asparaginase.

Main Methods

A multicenter retrospective study included 844 newly diagnosed ENKTL patients.
Multivariable analysis was performed to identify independent prognostic factors.
A scoring system (Huaihai Lymphoma Working Group-Natural killer/T-cell Lymphoma prognostic index, NPI) was developed based on significant variables.

Main Results

Eastern Cooperative Oncology Group performance status, lactate dehydrogenase, CA system, and albumin were identified as independent prognostic factors.
The developed Huaihai Lymphoma Working Group-NPI model stratified patients into four risk groups.
The 5-year overall survival rates for the four risk groups were 88.2%, 66.7%, 54.3%, and 30.5%.

Conclusions

The Huaihai Lymphoma Working Group-NPI is a feasible and effective prognostic stratification system for ENKTL patients.
This index aids in predicting outcomes for ENKTL patients receiving pegaspargase/L-asparaginase-based therapies.

Keywords:

ENKTL high-risk model pegaspargase/L-asparaginase prognostic