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Association of RAN and RANBP2 Gene Polymorphisms With Glioma Susceptibility in Chinese Children

Qianru Lin1, Wei Chen2, Jiating Tan1

  • 1Department of Hematology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

Cancer Reports (Hoboken, N.J.)
|July 23, 2024
PubMed
Abstract

Insights

Genetic variations in RAN and RANBP2 genes do not significantly increase glioma risk in Chinese children. Further research is needed to identify genetic markers for pediatric brain tumors.

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • Glioma is the most common pediatric central nervous system malignancy.
  • RAN (RAS oncogene family) regulates microtubule polymerization during mitosis.
  • RAN binding protein 2 (RANBP2) is implicated in DNA replication, mitosis, metabolism, and tumorigenesis.

Purpose of the Study:

  • To investigate the association between RAN and RANBP2 gene polymorphisms and glioma susceptibility in Chinese children.
  • To determine if specific genetic variations in RAN and RANBP2 influence the risk of developing pediatric glioma.

Main Methods:

  • A case-control study involving 191 pediatric glioma patients and 248 healthy children.
  • Gene polymorphisms were analyzed using polymerase chain reaction-based TaqMan sequencing.
  • Logistic regression models assessed the odds ratios and confidence intervals for specific gene polymorphisms (RAN rs56109543, rs7132224, rs14035; RANBP2 rs2462788).

Main Results:

  • No statistically significant correlation was found between the studied RAN and RANBP2 gene polymorphisms and glioma risk in Chinese children (p > 0.05).
  • Stratified analyses based on age, gender, tumor subtype, and clinical stage did not reveal significant associations.
  • The specific genotypes analyzed (rs56109543 C>T, rs7132224 A>G, rs14035 C>T, and rs2462788 C>T) did not appear to influence glioma susceptibility.

Conclusions:

  • The investigated RAN and RANBP2 gene polymorphisms are not statistically associated with glioma susceptibility in the Chinese pediatric population.
  • Further studies are required to explore other potential functional gene polymorphism loci of RAN and RANBP2.
  • Identifying novel genetic biomarkers for pediatric glioma remains an ongoing research objective.
Keywords:
RANRANBP2gliomapolymorphismsusceptibility

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