The 6Ps of Preparing a Manuscript: Prior Preparation Prevents Potentially Poor Performance

The process of writing a scientific document, whether it be a PhD thesis, a paper, review, chapter, book or even a book series, always begins with only one word. Why can writing a manuscript be so difficult to start? If there are sufficient data for the task, there is only one reason; vacillation. To address this serious and psychologically debilitating issue, this perspective will discuss the ethos of publishing and provide a solution for vacillation. The concept of sufficient novel data will be examined along with the criteria for identifying an appropriate home for a manuscript. The bare process of preparation will be described, which ultimately relies on discipline, routine, formatting and further discipline, with the ultimate goal being the production and quality control of a manuscript of the highest quality that you can achieve. The value of the secondary literature, namely reviews, chapters and books will be highlighted, specifically with regard to the building of a reputation and leaving a lasting legacy. The psychology of publishing, particularly dealing with success and failure will be covered, as this topic is often overlooked, and can have serious and deleterious mental health consequences. A balanced view of publication metrics will be given, showing that such factors are in some cases, purely a business strategy for publishing houses. Ideas to build one's career through networking, reviewing and being an ambassador for one's discipline are also given. As a former member of the Editorial Advisory Board of the Journal of Natural Products (2018-2022), an overview of the manuscript writing process from a personal and professional perspective is emphasized to encourage all to avoid the trials and tribulations of procrastination.