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Updated: Jun 19, 2025
A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
Published on: January 11, 2020
Mild Cognitive Impairment: Clinical Presentation and Short-Term Comparative Outcome of Patients With Potentially
Kavita Moria1, Arvind Sharma2,3, Pir Dutt Bansal2
1Department of Psychiatry, District Hospital, Tarn Taran, India.
Abstract:
Objective: To estimate the prevalence and study the clinical presentation of mild cognitive impairment (MCI), assess its outcome in terms of cognition and quality of life, identify factors for reversion to baseline, and compare these factors in the modifiable and nonmodifiable risk factor groups.
Abstract:
Methods: Individuals aged >50 years with memory/cognitive complaint(s) were screened using the Mini-Cog over 1 year (August 2018-August 2019). Those meeting the DSM-5 criteria for MCI were enrolled, and risk factors (modifiable and nonmodifiable) were noted. Assessments were done using the Hindi version of the Montreal Cognitive Assessment (H-MoCA), the Clinical Dementia Rating (CDR)-Hindi version, and the World Health Organization Quality of Life-Brief Hindi version. Treatment outcome was assessed at 6 months and compared between the risk factor groups. Factors for reversion of MCI were assessed.
Abstract:
Results: A total of 124 patients (22.1% of 561 with cognitive complaints) had MCI, and 100 patients (50 patients from the modifiable group and 50 patients from the nonmodifiable group) completed the study. Depression (52%) and hypertension (48%) were common risk factors. End point cognition scores were similar in both groups, with quality of life better in the modifiable group (P = .023). Age was negatively correlated with cognition in total patients and the nonmodifiable group (r =0.283-0.420; P = .002-.004). In total patients, cognition moderately correlated with education and somewhat with quality of life; 31% and 57% reverted to normal on the MoCA and CDR scales, respectively, while 1 progressed to dementia. Reverters had higher baseline H-MoCA scores (odds ratio [OR] = 6.996; P < .001) and were treated with cholinesterase inhibitors + vitamin E (OR = 28.999; P = .007).
Abstract:
Conclusion: Short-term outcome for both the modifiable and nonmodifiable risk factor groups was favorable. Higher education positively correlated with cognition, which itself predicted a better quality of life. Reverters of MCI had better baseline cognition and were treated with cholinesterase inhibitors + vitamin E.
Abstract:
Prim Care Companion CNS Disord 2024;26(4):24m03708.
Abstract:
Author affiliations are listed at the end of this article.
Insights
Mild cognitive impairment (MCI) affects over 20% of individuals over 50. Favorable short-term outcomes were observed, with higher education and specific treatments improving cognition and quality of life.
Area of Science:
- Neurology
- Geriatrics
- Cognitive Science
Background:
- Mild cognitive impairment (MCI) is a growing concern in aging populations.
- Understanding MCI prevalence, clinical presentation, and outcomes is crucial for effective management.
Purpose of the Study:
- To estimate MCI prevalence and clinical features in individuals over 50.
- To assess MCI outcomes regarding cognition and quality of life.
- To identify factors, including modifiable and non-modifiable risks, associated with MCI reversion.
Main Methods:
- Screening of individuals >50 years with cognitive complaints using Mini-Cog.
- Enrollment of participants meeting DSM-5 criteria for MCI, followed by risk factor assessment.
- Utilized Hindi versions of MoCA, CDR, and WHOQOL-BREF for assessments at baseline and 6 months.
Main Results:
- MCI prevalence was 22.1% (124/561); 100 patients completed the study.
- Depression and hypertension were common risk factors.
- Cognition scores were similar between modifiable and non-modifiable groups, but quality of life was better in the modifiable group (P=.023).
- 31% and 57% reverted to normal on MoCA and CDR scales, respectively.
- Reversion was associated with higher baseline H-MoCA scores (OR=6.996) and treatment with cholinesterase inhibitors + vitamin E (OR=28.999).
Conclusions:
- Short-term outcomes for MCI patients were favorable across both modifiable and non-modifiable risk factor groups.
- Higher education positively correlated with cognitive function, predicting better quality of life.
- Reversion to normal cognition was linked to better baseline cognitive status and specific pharmacological interventions.
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