Related Experiment Video

Updated: Jun 19, 2025

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
04:01

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

Published on: March 15, 2024

929

Linking homocysteine and ferroptosis in cardiovascular disease: insights and implications

Xiaozhong Li1,2, Zheng Zhou1,2, Yu Tao1

  • 1Department of Cardiovascular Medicine, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China.

Apoptosis : an International Journal on Programmed Cell Death
|July 23, 2024
PubMed

Insights

Homocysteine (Hcy) contributes to cardiovascular disease (CVD) risk. This review explores how Hcy influences ferroptosis, a cell death pathway implicated in CVD, to advance understanding of disease mechanisms.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Cardiovascular Medicine

Background:

  • Homocysteine (Hcy) is a methionine metabolite linked to cardiovascular disease (CVD).
  • Ferroptosis, a cell death form marked by iron and lipid peroxidation, is implicated in various diseases, including CVD.
  • The specific impact of Hcy on ferroptosis remains underexplored.

Purpose of the Study:

  • To investigate the potential roles and mechanisms of homocysteine in ferroptosis within cardiovascular disease.
  • To summarize recent findings on the effects of Hcy on ferroptosis in CVD.

Main Methods:

  • Comprehensive literature research and analysis.
  • Review of existing studies on homocysteine, ferroptosis, and cardiovascular disease.

Main Results:

  • Emerging evidence suggests a link between elevated homocysteine levels and ferroptosis induction.
  • Homocysteine may promote ferroptosis through mechanisms involving oxidative stress and iron metabolism.
  • Ferroptosis activation by homocysteine could contribute to cardiovascular tissue damage.

Conclusions:

  • Homocysteine plays a significant role in promoting ferroptosis, exacerbating cardiovascular disease pathology.
  • Understanding the Hcy-ferroptosis axis offers novel therapeutic targets for CVD.
  • Further research is needed to fully elucidate the molecular mechanisms involved.

Keywords:
Cardiovascular diseaseFerroptosisHomocysteine

More Related Videos

Ferric Chloride-induced Murine Thrombosis Models10:37

Ferric Chloride-induced Murine Thrombosis Models

Published on: September 5, 2016

21.6K
Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining07:32

Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining

Published on: May 23, 2025

139

Related Concept Videos

Necrosis01:16

Necrosis

Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
4.4K
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
69
Peroxisomes01:24

Peroxisomes

Peroxisomes are specialized organelles present in fungi, plant, and animal cells. It can vary in number, size, morphology, and activity depending on the type of tissue and the nutritional state of the cell. For example, cells with active lipid metabolism, such as adipocytes, neurons, and hepatocytes, have more peroxisomes than other cells in the body. Besides their primary role in breaking down complex organic molecules, peroxisomes can also synthesize specific macromolecules and participate in...
11.7K
Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
9.5K
Translation01:31

Translation

Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Proteins are...
14.7K
The Early Endosome: Endocytosis of Transferrin01:28

The Early Endosome: Endocytosis of Transferrin

Essential proteins such as insulin or low-density lipoprotein (LDL) and micronutrients such as iron enter a eukaryotic cell through receptor-mediated endocytosis. Subsequently, the early endosomes fuse with the vesicles containing such receptor-ligand complexes and play a vital role in sorting the incoming ligands and receptors. While the ligands are either degraded inside the vesicle or released into the cytosol, their receptors are returned to the plasma membrane for further rounds of...
3.3K