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Author Spotlight: Exploring the Lifespan Dynamics of Healthy Human Hematopoiesis
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Emergency myelopoiesis in solid cancers.

Konstantinos Aliazis1, Sasitorn Yenyuwadee1,2, Ployploen Phikulsod3

  • 1Department of Hematology-Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.

British Journal of Haematology
|July 23, 2024
PubMed
Summary

Solid cancers can disrupt normal blood cell production by affecting hematopoietic stem and progenitor cells (HSPCs). This disruption can lead to the development of immunosuppressive myeloid cells, impacting anti-tumor responses.

Keywords:
cancerclonal hematopoiesisemergency myelopoiesismyeloid derived suppressor cellsmyelopoiesistumour associated macrophages

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Area of Science:

  • Immunology
  • Hematopoiesis
  • Cancer Biology

Background:

  • Immune cells originate from hematopoietic stem and progenitor cells (HSPCs).
  • HSPCs normally differentiate and proliferate but can be mobilized for emergency myelopoiesis in response to injury or infection.
  • Solid tumors can mimic emergency myelopoiesis signals, aberrantly influencing myeloid cell development.

Purpose of the Study:

  • To review the literature on how solid cancers affect HSPC function.
  • To discuss the potential impact of these effects on anti-tumor immunity.

Main Methods:

  • Literature review and synthesis of existing research on cancer-HSPC interactions.
  • Analysis of mechanisms by which tumors influence myelopoiesis.

Main Results:

  • Solid tumors secrete factors that can promote myelopoiesis.
  • Tumor-induced myelopoiesis can lead to the generation of immunosuppressive myeloid cells.
  • These effects on HSPCs occur systemically, beyond the tumor microenvironment.

Conclusions:

  • Solid cancers significantly impact HSPC function, redirecting myeloid development.
  • This aberrant myelopoiesis contributes to an immunosuppressive environment, potentially hindering anti-tumor responses.
  • Understanding these systemic effects is crucial for developing effective cancer immunotherapies.