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Related Experiment Video

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Association between Resting Heart Rate and Machine Learning-Based Brain Age in Middle- and Older-Age.

J Wang1, H Huang, W Yang

  • 1Weili Xu, Professor, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Tomtebodavägen 18A Floor 10, Solna 17165, Sweden; Phone: +46 8 524 858 26; Email: weili.xu@ki.se, Xiangyu Ma, Professor, Department of Epidemiology, College of Preventive Medicine, Third Military Medical University, Gaotanyan Street 30, Shapingba District, Chongqing 400038, China, Phone: + 023-68771540;

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Summary
This summary is machine-generated.

Higher resting heart rate (RHR) is linked to accelerated brain aging, even in middle-aged adults. Lower RHR (<60 bpm) is associated with younger brain age, suggesting RHR may indicate brain aging rate.

Keywords:
Resting heart rateUK Biobankbrain agemagnetic resonance imaging

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Area of Science:

  • Neuroimaging
  • Cardiovascular Health
  • Aging Research

Background:

  • Resting heart rate (RHR) is a known risk factor for dementia.
  • The association between RHR and brain age remains unclear.

Purpose of the Study:

  • To investigate the link between RHR and brain age.
  • To explore the relationship between RHR and brain age gap (BAG).
  • Utilize multimodal MRI in mid- and old-aged adults.

Main Methods:

  • Longitudinal study using UK Biobank neuroimaging data.
  • 33,381 participants (mean age 54.74 years).
  • Brain age predicted via multimodal MRI; RHR categorized (<60, 60-69, 70-79, ≥80 bpm).

Main Results:

  • Higher RHR (≥70 bpm) correlated with older brain age and larger BAG.
  • Lower RHR (<60 bpm) associated with younger brain age and smaller BAG.
  • Associations were consistent across age groups, with some variations for lower RHR.

Conclusions:

  • Elevated RHR (>80 bpm) is associated with accelerated brain aging.
  • Lower RHR (<60 bpm) is linked to younger brain age.
  • RHR may serve as a biomarker for brain aging.