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Perceived Cognitive Function and Glycemic Variability: Baseline Results From a Cognitive Rehabilitation Intervention.

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High glucose variability in type 2 diabetes is linked to poorer perceived cognitive function and self-management. Addressing glucose control may improve cognitive health in diabetic patients.

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Area of Science:

  • Endocrinology
  • Neuroscience
  • Psychology

Background:

  • Type 2 diabetes is associated with cognitive impairment.
  • Glucose variability is a potential contributing factor to cognitive decline.
  • Effective diabetes self-management is crucial for overall health.

Purpose of the Study:

  • To investigate the relationship between glucose variability, diabetes self-management, and cognitive function.
  • To analyze these associations in individuals with type 2 diabetes undergoing cognitive rehabilitation.
  • To identify potential targets for interventions aimed at improving cognitive health in this population.

Main Methods:

  • Analysis of baseline data from the Memory, Attention, and Problem-Solving Skills for Diabetes trial (n=95).
  • Inclusion of perceived cognitive function scores (PROMIS Cognitive Function v2).
  • Inclusion of continuous glucose monitoring data for glucose variability and diabetes self-care activities.

Main Results:

  • Participants reported higher cognitive dysfunction than the general US population.
  • Lower perceived cognitive function scores correlated with higher glucose variability.
  • Improved perceived cognitive health was associated with better diabetes self-management.
  • Glucose variability significantly predicted perceived cognitive function.

Conclusions:

  • Perceived cognitive function is interconnected with diabetes self-management and glucose variability.
  • Interventions targeting glucose variability may mitigate cognitive changes.
  • Assessing perceived cognitive function can signal the need for enhanced diabetes support or further cognitive evaluation.