Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Incomplete Dominance01:43

Incomplete Dominance

22.3K
Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
22.3K
Conservation of Small Populations02:04

Conservation of Small Populations

13.1K
Small population sizes put a species at extreme risk of extinction due to a lack of variation, and a consequent decrease in adaptability. This weakens the chances of survival under pressures such as climate change, competition from other species, or new diseases. Large populations are more likely to survive pressures such as these, as such populations are more likely to harbor individuals that have genetic variants that are adaptive under new stresses. Small populations are much less...
13.1K
Cloning of Dolly the Sheep01:08

Cloning of Dolly the Sheep

3.4K
The first successfully cloned mammal was Dolly, a sheep, born on 5th July 1996 at Roslin Institute, Scotland. The cloned sheep was named after the American singer Dolly Parton. Dolly lived for seven years and died of respiratory complications, which is speculated to be due to the actual age of her DNA. Because the DNA in cloned cells belongs to an older individual,  the cloned individual’s life expectancy may be affected. Indeed, analysis of Dolly’s DNA revealed shorter...
3.4K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

13.3K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
13.3K
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

348
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
348
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

5.7K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
5.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

FaWRKY21 Enhances Postharvest Resistance to <i>Botrytis cinerea</i> in Strawberry by Activating Jasmonic Acid Biosynthesis.

Journal of agricultural and food chemistry·2026
Same author

Integrating genetic, epigenetic, and clinical signatures via machine learning for robust prediction of leflunomide response in rheumatoid arthritis: a multi-center validation study.

Frontiers in immunology·2026
Same author

Cardiovascular Toxicity of BTKi in Chronic B-Cell Malignancies.

Reviews in cardiovascular medicine·2026
Same author

Incorporation of Engineered Cu<sup>0</sup>/Cu<sup>+</sup> Interfaces in Metal-Organic Frameworks for Boosting CO<sub>2</sub> Hydrogenation to Methanol.

Angewandte Chemie (International ed. in English)·2026
Same author

Graph Neural Network-Assisted Machine Learning for High-Throughput Buried Interfacial Materials Screening in Antisolvent-Free Perovskite Solar Cells.

ACS applied materials & interfaces·2026
Same author

BMI-genome interactions regulate global gene expression with emphasis in brain and gut.

Cell genomics·2026

Related Experiment Video

Updated: Jun 19, 2025

Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings
14:40

Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings

Published on: October 25, 2015

9.4K

Sheep litter size heredity basis using genome-wide selective analysis.

Weiguo Cui1, Hechuan Wang1, Jingchun Li1

  • 1College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, China.

Reproduction in Domestic Animals = Zuchthygiene
|July 24, 2024
PubMed
Summary

Researchers identified 65 candidate genes linked to litter size in sheep using whole-genome data. These genes, involved in reproduction and development, offer insights into sheep fecundity and potential for breeding improvements.

Keywords:
genome‐wide selective analysisheredity basislitter sizesheep

More Related Videos

Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis
10:08

Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis

Published on: August 12, 2019

17.0K
Protocol for Assessing the Relative Effects of Environment and Genetics on Antler and Body Growth for a Long-lived Cervid
09:09

Protocol for Assessing the Relative Effects of Environment and Genetics on Antler and Body Growth for a Long-lived Cervid

Published on: August 8, 2017

7.4K

Related Experiment Videos

Last Updated: Jun 19, 2025

Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings
14:40

Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings

Published on: October 25, 2015

9.4K
Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis
10:08

Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis

Published on: August 12, 2019

17.0K
Protocol for Assessing the Relative Effects of Environment and Genetics on Antler and Body Growth for a Long-lived Cervid
09:09

Protocol for Assessing the Relative Effects of Environment and Genetics on Antler and Body Growth for a Long-lived Cervid

Published on: August 8, 2017

7.4K

Area of Science:

  • Animal Genetics
  • Genomics
  • Reproductive Biology

Background:

  • Sheep breeds exhibit significant variations in economically important traits, including litter size, influenced by diverse environments and selective pressures.
  • Certain indigenous Chinese sheep breeds display a high litter size phenotype, making them valuable models for studying fecundity.

Purpose of the Study:

  • To identify candidate genes associated with litter size in sheep using selective signal analysis.
  • To understand the genetic basis of sheep fecundity and provide targets for molecular breeding.

Main Methods:

  • Whole-genome sequencing data from 60 sheep across eight breeds were analyzed.
  • Selective signal analysis, including pairwise fixation index (FST) and cross-population extended haplotype homozygosity (XP-EHH), was employed to pinpoint candidate genes.
  • Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed on identified candidate genes.

Main Results:

  • A total of 34,065,017 single-nucleotide polymorphisms (SNPs) were identified.
  • 65 candidate genes (CDGs) were pinpointed, with 41 annotated to 576 GO terms, including seven directly related to follicular and embryonic development.
  • 21 CDGs were enriched in 73 KEGG pathways, notably those involved in Hippo, TGF-β, PI3K-Akt, and Jak-STAT signaling.

Conclusions:

  • Several candidate genes are under strong selection in sheep with high litter size traits.
  • The findings enhance the understanding of the genetic architecture of sheep litter size.
  • Identified candidate genes provide valuable targets for future molecular breeding strategies to improve sheep fecundity.