Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell Motility through Blebbing01:16

Cell Motility through Blebbing

1.9K
Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
Blebbing Through the Matrix
In multicellular...
1.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same authorSame journal

Non-equilibrium phase transitions in hybrid Voronoi models of cell colonies.

Soft matter·2026
Same author

From biting to engulfment: curvature-actin coupling controls phagocytosis of soft, deformable targets.

bioRxiv : the preprint server for biology·2026
Same author

Modelling chemotaxis of branched cells in complex environments provides insights into immune cell navigation.

PLoS computational biology·2026
Same author

Scaling the glassy dynamics of active particles: Tunable fragility and reentrance.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Trade-off between branching and polarity controls decision-making during cell migration.

Science advances·2026
Same author

Coupling anisotropic curvature and nematic order: mechanisms of membrane shape remodeling.

Soft matter·2025
Same journal

Nanopore sequencing with proteins: synchronization and dischronization of molecular dynamics simulations with laboratory and industrial developments.

Soft matter·2026
Same journal

Catanionics from biosurfactants and regular surfactants: miscibility and structure.

Soft matter·2026
Same journal

Adhesives with a thickness smaller than the fractocohesive length enhance adhesion.

Soft matter·2026
Same journal

Effects of methoxy substituents on self-assembly and gelation performance of benzamide-based organogelators.

Soft matter·2026
Same journal

Rheology of <i>Escherichia coli</i> suspensions with various bacterial morphologies and motion characteristics.

Soft matter·2026
See all related articles

Related Experiment Video

Updated: Jun 19, 2025

Preparation and Structural Evaluation of Epithelial Cell Monolayers in a Physiologically Sized Microfluidic Culture Device
07:38

Preparation and Structural Evaluation of Epithelial Cell Monolayers in a Physiologically Sized Microfluidic Culture Device

Published on: July 1, 2022

1.3K

Motility driven glassy dynamics in confluent epithelial monolayers.

Souvik Sadhukhan1, Manoj Kumar Nandi2, Satyam Pandey1

  • 1Tata Institute of Fundamental Research, 36/P Gopanpally Village, Hyderabad-500046, India. ssadhukhan@tifrh.res.in.

Soft Matter
|July 24, 2024
PubMed
Summary
This summary is machine-generated.

This study introduces a new theory for cell motility in epithelial tissues, explaining how cell movement influences their solid-like or fluid-like states during development and disease. The findings reveal how effective persistence time scales with cell shape dynamics.

More Related Videos

Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration
10:53

Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration

Published on: October 13, 2019

7.0K
The Mechanics of Poro-Elastic Contractile Actomyosin Networks As a Model System of the Cell Cytoskeleton
08:50

The Mechanics of Poro-Elastic Contractile Actomyosin Networks As a Model System of the Cell Cytoskeleton

Published on: March 10, 2023

762

Related Experiment Videos

Last Updated: Jun 19, 2025

Preparation and Structural Evaluation of Epithelial Cell Monolayers in a Physiologically Sized Microfluidic Culture Device
07:38

Preparation and Structural Evaluation of Epithelial Cell Monolayers in a Physiologically Sized Microfluidic Culture Device

Published on: July 1, 2022

1.3K
Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration
10:53

Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration

Published on: October 13, 2019

7.0K
The Mechanics of Poro-Elastic Contractile Actomyosin Networks As a Model System of the Cell Cytoskeleton
08:50

The Mechanics of Poro-Elastic Contractile Actomyosin Networks As a Model System of the Cell Cytoskeleton

Published on: March 10, 2023

762

Area of Science:

  • Biophysics
  • Cell Biology
  • Condensed Matter Physics

Background:

  • Cellular monolayers transition between solid-like jammed and fluid-like flowing states during biological processes.
  • The epithelial-to-mesenchymal transition (EMT) involves cells becoming motile, impacting tissue dynamics.
  • Understanding the interplay between cell motility and glassy dynamics is crucial for processes like embryonic development and cancer progression.

Purpose of the Study:

  • To develop an analytical framework explaining how cell motility drives glassy dynamics in epithelial systems.
  • To provide deeper insights into the mechanisms underlying the epithelial-to-mesenchymal transition (EMT).

Main Methods:

  • Development of a novel analytical theory inspired by established glass theory.
  • Utilizing simulations of the active Vertex model to test theoretical predictions.
  • Investigating the role of effective persistence time-scale and rotational diffusivity.

Main Results:

  • A crucial finding is that confluency affects the effective persistence time-scale of active force (Deffr).
  • Deffr differs from bare rotational diffusivity (Dr) due to cell shape dynamics, which rectify force dynamics.
  • The theory predicts that Deffr saturates at large Dr values and equals Dr at small Dr values.

Conclusions:

  • The developed theory provides essential insights into active glassy dynamics in epithelial monolayers.
  • The novel effect of Deffr is critical for interpreting existing and new simulation data.
  • This work offers a framework for understanding how cell motility influences tissue-level behaviors during biological transitions.