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Updated: Jun 19, 2025

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
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Biochemical hallmarks-targeting antineoplastic nanotherapeutics

Jing Han1, He Dong1, Tianyi Zhu1

  • 1Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Bone Tumor Institution, 100 Haining Street, Shanghai, 200080, PR China.

Bioactive Materials
|July 24, 2024
PubMed

Insights

Tumor microenvironments (TMEs) are crucial in cancer development and treatment resistance. Nanotechnology offers novel nanotherapeutics to target TMEs, improving cancer therapy efficacy and overcoming resistance.

Area of Science:

  • Oncology
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Tumor microenvironments (TMEs) significantly influence cancer progression, metastasis, and therapeutic resistance.
  • Nanotechnology advancements enable the development of nanomedicines targeting TME-specific characteristics.
  • Aberrant TME hallmarks include acidosis, hypoxia, and dysregulated metabolism, presenting therapeutic challenges.

Purpose of the Study:

  • To review the role of TMEs in cancer.
  • To discuss nanotechnology-based strategies for TME modulation.
  • To explore challenges and future directions for nanotherapeutics in TME modulation.

Main Methods:

  • Literature review of TME characteristics and nanotherapeutic strategies.
  • Analysis of TME-responsive nanomedicine design and fabrication.
  • Discussion of biochemical TME modulation (acidosis, hypoxia, metabolism).

Main Results:

  • Nanotherapeutics can be designed for active targeting and TME-responsiveness.
  • Nanomedicines can overcome biological barriers and enhance therapeutic outcomes.
  • Modulating biochemical TME factors offers promising anti-cancer strategies.

Conclusions:

  • Smart anti-cancer nanotherapeutics hold potential for TME modulation.
  • Combination therapies involving nanotherapeutics and traditional treatments are key for clinical translation.
  • Further research is needed to address challenges in nanotherapeutic development for TME targeting.
Keywords:
Biochemical hallmarkCancer therapyControlled drug deliveryNanoparticleTumor microenvironment

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