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Ceramides: Shared Lipid Biomarkers of Cardiovascular Disease and Schizophrenia

Anna I Tkachev, Elena A Stekolshchikova, Anna Yu Morozova

    Consortium Psychiatricum
    |July 24, 2024
    PubMed

    Insights

    Schizophrenia patients show altered blood plasma levels of three key ceramide species, particularly Cer(d18:1/18:0). These findings suggest shared metabolic abnormalities link schizophrenia and cardiovascular disease.

    Area of Science:

    • Biochemistry
    • Psychiatry
    • Cardiology

    Background:

    • Schizophrenia is linked to cardiovascular disease, a leading cause of mortality in patients.
    • Shared genetic factors suggest underlying metabolic abnormalities.
    • Specific blood plasma ceramides are implicated in cardiovascular disease risk.

    Purpose of the Study:

    • To compare blood plasma levels of three ceramide species (Cer(d18:1/16:0), Cer(d18:1/18:0), and Cer(d18:1/24:1)) between schizophrenia patients and healthy controls.

    Main Methods:

    • Quantified three specific ceramide species in blood plasma from 82 schizophrenia patients and 138 controls.
    • Validated findings in an independent cohort including first-episode psychosis patients.

    Main Results:

    • All three measured ceramide species showed significant alterations in schizophrenia patients compared to controls.
    • Cer(d18:1/18:0) exhibited the most pronounced concentration difference.

    Conclusions:

    • Altered levels of these ceramides may indicate common metabolic pathways in schizophrenia and cardiovascular disease.
    • Ceramide profiling could offer insights into shared pathophysiology and potential biomarkers.
    Abstract

    Keywords:
    blood plasmacardiovascular diseaseceramidelipidschizophrenia

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