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Utilizing the Modified T-Maze to Assess Functional Memory Outcomes After Cardiac Arrest

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Published on: January 5, 2018

Brain network changes and cognitive function after cardiac arrest.

Pardis Zarifkar¹, Mette Kirstine Wagner², Patrick MacDonald Fisher^3,4

¹Department of Neurology, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark.

Brain Communications

|July 24, 2024

Summary

This summary is machine-generated.

Out-of-hospital cardiac arrest survivors often experience persistent cognitive impairments, particularly in executive and visuospatial functions. Brain network changes, like increased frontoparietal connectivity, correlate with poorer cognitive outcomes.

Keywords:

brain mapping cardiac arrest cognitive dysfunction functional neuroimaging neural networks

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Published on: November 19, 2012

Area of Science:

Neuroscience
Cardiology
Cognitive Science

Background:

Survival rates for out-of-hospital cardiac arrest (OHCA) have improved.
Long-term cognitive impairment is common in OHCA survivors, even with early consciousness recovery.
Determinants and mechanisms of cognitive deficits post-OHCA are not well understood.

Purpose of the Study:

To investigate cognitive outcomes and brain network alterations in OHCA survivors.
To identify factors associated with cognitive impairment after OHCA.
To explore the utility of functional MRI in assessing cognitive deficits.

Main Methods:

Utilized the REcovery after cardiac arrest surVIVAL (RESCUE) cohort of OHCA survivors.
Correlated cognition measurements (Montreal Cognitive Assessment, comprehensive neuropsychological assessment) with resting-state functional MRI data.
Compared brain network connectivity in survivors to healthy controls.

Main Results:

Approximately 50% of OHCA survivors showed cognitive impairments at discharge, persisting at three months.
Executive and visuospatial functions were particularly affected.
OHCA survivors exhibited increased resting-state network connectivity, especially involving the frontoparietal network.
Increased frontoparietal-visual network connectivity correlated with poorer cognitive outcomes (β = 14.0, P = 0.01).
Higher education appeared to offer some cognitive protection (β = -2.06, P = 0.03).

Conclusions:

Subtle cognitive impairment is significant in OHCA survivors eligible for home discharge.
Functional MRI can identify brain network alterations linked to cognitive outcomes post-OHCA.
Understanding these alterations is crucial for improving long-term recovery and patient management.