Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Types of Toxins01:36

Types of Toxins

3.6K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
3.6K
Toxic Reactions: Overview01:26

Toxic Reactions: Overview

4.1K
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
4.1K
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

379
Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
379
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

271
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
271
Bioactivation and Tissue Toxicity01:25

Bioactivation and Tissue Toxicity

151
Bioactivation is a metabolic process that transforms less reactive substances into highly reactive metabolites, initiating tissue toxicity. This transformation can lead to various toxic effects, including carcinogenesis and teratogenesis. Reactive metabolites are classified into two main types: electrophiles and free radicals.Electrophiles are electron-deficient species and are produced primarily by the enzyme cytochrome P-450 during the metabolism of compounds containing carbon, nitrogen, or...
151
Toxicity Testing in Animals01:23

Toxicity Testing in Animals

200
Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
200

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dolabranes from the Chinese Mangrove, Ceriops tagal.

Journal of natural products·2010
Same author

Electrospinning of small diameter 3-D nanofibrous tubular scaffolds with controllable nanofiber orientations for vascular grafts.

Journal of materials science. Materials in medicine·2010
Same author

Targeting human clonogenic acute myelogenous leukemia cells via folate conjugated liposomes combined with receptor modulation by all-trans retinoic acid.

International journal of pharmaceutics·2010
Same author

The promotion of neural regeneration in an extreme rat spinal cord injury model using a collagen scaffold containing a collagen binding neuroprotective protein and an EGFR neutralizing antibody.

Biomaterials·2010
Same author

Significant evidence of association between polymorphisms in ZNF533, environmental factors, and nonsyndromic orofacial clefts in the Western Han Chinese population.

DNA and cell biology·2010
Same author

[Surgical outcomes of pediatric symptomatic epilepsy and their influencing factors].

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics·2010

Related Experiment Video

Updated: Apr 26, 2026

A Net Mold-based Method of Scaffold-free Three-Dimensional Cardiac Tissue Creation
06:57

A Net Mold-based Method of Scaffold-free Three-Dimensional Cardiac Tissue Creation

Published on: August 5, 2018

8.9K

3D printing tissue-engineered scaffolds for auricular reconstruction.

Shuyi Gao1,2, Tianqi Nie1,2, Ying Lin3,4

  • 1Department of Otorhinolaryngology Head and Neck Surgery, Guangzhou Twelfth People's Hospital (The Affiliated Twelfth People's Hospital of Guangzhou Medical University), Guangzhou Medical University, Guangzhou, 510620, China.

Materials Today. Bio
|July 24, 2024
PubMed
Summary

3D printed biomaterial scaffolds offer a promising alternative to traditional rib cartilage grafts for congenital microtia reconstruction. This approach aims to overcome donor site complications and advance cartilage tissue engineering for auricular defects.

Keywords:
3D printingAuricular reconstructionBiomaterial scaffoldsMicrotiaTissue engineering

More Related Videos

Novel Process for 3D Printing Decellularized Matrices
08:14

Novel Process for 3D Printing Decellularized Matrices

Published on: January 7, 2019

7.1K
Tissue-Engineered Graft for Circumferential Esophageal Reconstruction in Rats
08:56

Tissue-Engineered Graft for Circumferential Esophageal Reconstruction in Rats

Published on: February 10, 2020

7.1K

Related Experiment Videos

Last Updated: Apr 26, 2026

A Net Mold-based Method of Scaffold-free Three-Dimensional Cardiac Tissue Creation
06:57

A Net Mold-based Method of Scaffold-free Three-Dimensional Cardiac Tissue Creation

Published on: August 5, 2018

8.9K
Novel Process for 3D Printing Decellularized Matrices
08:14

Novel Process for 3D Printing Decellularized Matrices

Published on: January 7, 2019

7.1K
Tissue-Engineered Graft for Circumferential Esophageal Reconstruction in Rats
08:56

Tissue-Engineered Graft for Circumferential Esophageal Reconstruction in Rats

Published on: February 10, 2020

7.1K

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Congenital microtia, a common auricular defect, is often treated with autologous rib cartilage grafts.
  • Rib cartilage harvesting poses risks, including donor site morbidity like pneumothorax and scarring.
  • There is a need for alternative graft materials with improved biocompatibility and non-invasive properties.

Purpose of the Study:

  • To review the development and application of 3D printed biomaterial scaffolds in auricular reconstruction.
  • To highlight the potential of these scaffolds as alternatives to autologous grafts.
  • To guide future research in cartilage tissue engineering for auricular defects.

Main Methods:

  • Review of existing literature on 3D printing biomaterial scaffolds for auricular reconstruction.
  • Analysis of scaffold properties such as histocompatibility, morphological control, and invasiveness.
  • Discussion of current challenges and future directions in the field.

Main Results:

  • 3D printing allows for precise control over scaffold morphology, mimicking natural ear structures.
  • Biomaterial scaffolds offer potential for reduced donor site morbidity compared to rib cartilage.
  • The review synthesizes current knowledge on the exploit and application of these scaffolds.

Conclusions:

  • 3D printed biomaterial scaffolds represent a significant advancement in auricular reconstruction.
  • Further research is needed to address challenges for widespread clinical application and long-term efficacy.
  • This technology holds promise for improving cartilage tissue engineering and treating auricular defects.