Related Experiment Video
Updated: Jun 19, 2025

Ex Vivo Assessment of Contractility, Fatigability and Alternans in Isolated Skeletal Muscles
Published on: November 1, 2012
CRITICAL ANALYSIS OF HYPERCONTRACTILE WAVES VIGOR TO DEFINE HYPERCONTRACTILE ESOPHAGUS DISEASE
Leonardo Yuri Kasputis Zanini1, Fernando A M Herbella2, Marco G Patti3
1Department of Surgery, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, Brazil.
Background:
The current definition for hypercontractile esophagus was arbitrarily set at the uppermost range in volunteers for a specific equipment.
Objective:
This study aims to critically analyze the concept of hypercontractile waves to redefine hypercontractile esophagus parameters.
Methods:
We reviewed 500 unselected and consecutive HRM tests (5000 waves) performed in a water -perfused system.
Results:
Mean distal contractility integral (DCI) was 825±1492 (0-42775) mmHg.cm.s, two standard deviations above average = 3810; 95th percentile = 2798 mmHg.cm.s.
Conclusion:
In healthy volunteers, two standard deviations above average is 4000 mmHg.cm.s, we thus suggest this value to define hypercontractile waves and define hypercontractile esophagus in a water-perfused HRM system.
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